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T2 Toxin

T2 Toxin

Product ID T0002
Cas No. 21259-20-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $84.50 In stock
5 mg $332.50 In stock
10 mg $591.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

T2 toxin is a trichothecene mycotoxin initially produced by species of Fusarium. T2 toxin is often found in grains and grain products such as cereals and breads. T2 toxin may act as an anticoagulant at low doses, decreasing fibrinolytic and coagulant signaling pathways. In vivo, T2 toxin alters permeability of the blood-brain barrier (BBB). In the brain and spleen, T2 toxin induces oxidative stress by decreasing levels of glutathione and increasing levels of ROS and lipid peroxidation; it also decreases expression of tissue inhibitor of metalloproteinase 1 (TIMP-1) and increases expression of matrix metalloproteinase 9 (MMP9), TNF-α, IL-1β, and IL-6. In vitro, T2 toxin alters steroidogenesis by inhibiting production of follicular-stimulating hormone (FSH) and progesterone and inhibiting the stimulatory effects of IFG-1.

Product Info

Cas No.

21259-20-1

Purity

≥98%

Formula

C24H34O9

Formula Wt.

466.52

IUPAC Name

[(1S,2R,4S,7R,9R,10R,11S,12S)-11-acetyloxy-2-(acetyloxymethyl)-10-hydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-4-yl] 3-methylbutanoate

Synonym

Insariotoxin, T2 Trichothecene

Melting Point

151-152°C

Solubility

Dichloromethane, DMSO, Ethanol, Ethyl Acetate.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T0002 MSDS PDF

Info Sheet

T0002 Info Sheet PDF

References

Xu X, Madden LV, Edwards SG. Modeling the Effects of Environmental Conditions on HT2 and T2 Toxin Accumulation in Field Oat Grains. Phytopathology. 2014 Jan;104(1):57-66. PMID: 23883158.

Ravindran J, Agrawal M, Gupta N, et al. Alteration of blood brain barrier permeability by T-2 toxin: Role of MMP-9 and inflammatory cytokines. Toxicology. 2011 Feb 4;280(1-2):44-52. PMID: 21112371.

Caloni F, Ranzenigo G, Cremonesi F, et al. Effects of a trichothecene, T-2 toxin, on proliferation and steroid production by porcine granulosa cells. Toxicon. 2009 Sep 1;54(3):337-44. PMID: 19463844.

Johnsen H, Odden E, Johnsen BA, et al. Cytotoxicity and effects of T2-toxin on plasma proteins involved in coagulation, fibrinolysis and kallikrein-kinin system. Arch Toxicol. 1988 Jan;61(3):237-40. PMID: 3281632.

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