Bombesin

Product ID B5648

Cas No. 31362-50-2

Purity ≥95%

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Description
Product Info
Shipping and Storage
Downloads
References

Description
Product Info
Shipping and Storage
Downloads
References
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Description

Bombesin is a gastrin-releasing peptide (GRP) analog that stimulates intestinal function; it was originally found in Bombina toads and binds bombesin receptors (BBRs) and GRP receptors. Mammalian homologs of this compound are neuromedin B and GRP. Bombesin exhibits antiepileptic/anticonvulsant potential, potentiating GABA release by increasing extracellular Ca2+ influx and inducing membrane depolarization through the inhibition of inwardly rectifying (hERG) K+ channels. Bombesin also exhibits anorexigenic and carcinogenic (pro-cancer) activities.

Product Info

Cas No.	31362-50-2
Purity	≥95%
Formula	C₇₁H₁₁₁N₂₄O₁₈S
Formula Wt.	1619.86
Synonym	2-L-glutamine-6-L-asparagine-Alytesin
Solubility	Soluble in 5% acetic acid.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	B5648 MSDS PDF
Info Sheet	B5648 Info Sheet PDF

References

Zhang HP, Xiao Z, Cilz NI, et al. Bombesin facilitates GABAergic transmission and depresses epileptiform activity in the entorhinal cortex. Hippocampus. 2014 Jan;24(1):21-31. PMID: 23966303.

Weber HC. Regulation and signaling of human bombesin receptors and their biological effects. Curr Opin Endocrinol Diabetes Obes. 2009 Feb;16(1):66-71. PMID: 19115523.

Yamada K, Wada E, Wada K. Bombesin-like peptides: studies on food intake and social behaviour with receptor knock-out mice. Ann Med. 2000 Nov;32(8):519-29. PMID: 11127929.

Ohlsson B, Fredäng N, Axelson J. The effect of bombesin, cholecystokinin, gastrin, and their antagonists on proliferation of pancreatic cancer cell lines. Scand J Gastroenterol. 1999 Dec;34(12):1224-9. PMID: 10636070.