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Bergenin

Product ID B1769
Cas No. 477-90-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $157.40 In stock
5 mg $570.10 In stock
10 mg $832.50 Please Inquire
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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Bergenin is a trihydroxybenzoic acid glycoside found in Bergenia and other plant sources. Bergenin exhibits immunosuppressive, anti-inflammatory, anti-parasitic, antimalarial, analgesic, antinociceptive, antioxidative, anti-diabetic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. In vivo, bergenin downregulates expression of NF-κB and IKKβ, decreases IgG levels, cytokine release, and other immune response mediators, and suppresses development of edema. In vitro and in vivo, bergenin inhibits growth of Plasmodium. In other animal models, this compound inhibits mechanical hyperalgesia. In diabetic rats, bergenin decreases levels of blood glucose, total cholesterol, and LDL and increases levels of HDL, superoxide dismutase, and catalase. Additionally, bergenin inhibits tumor development induced by TPA and DMBA.

Product Info

Cas No.

477-90-7

Purity

≥98%

Formula

C14H16O9

Formula Wt.

328.27

IUPAC Name

3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a, 10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one;hydrate

Melting Point

237-240°C

Solubility

Slightly soluble in DMSO, methanol. Insoluble in water, ethanol.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B1769 MSDS PDF

Info Sheet

B1769 Info Sheet PDF

References

Jain SK, Singh S, Khajuria A, et al. Pyrano-isochromanones as IL-6 Inhibitors: Synthesis, in Vitro and in Vivo Antiarthritic Activity. J Med Chem. 2014 Aug 28;57(16):7085-97. PMID: 25111439.

Liang J, Li Y, Liu X, et al. In vivo and in vitro antimalarial activity of bergenin. Biomed Rep. 2014 Mar;2(2):260-264. PMID: 24649107.

Zhang J, Nishimoto Y, Tokuda H, et al. Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood. Chem Biodivers. 2013 Oct;10(10):1866-75. PMID: 24130029.

Kumar R, Patel DK, Prasad SK, et al. Type 2 antidiabetic activity of bergenin from the roots of Caesalpinia digyna Rottler. Fitoterapia. 2012 Mar;83(2):395-401. PMID: 22178680.

de Oliveira CM, Nonato FR, de Lima FO, et al. Antinociceptive properties of bergenin. J Nat Prod. 2011 Oct 28;74(10):2062-8. Erratum in: J Nat Prod. 2012 Feb 24;75(2):305. PMID: 21939182.

Wang X, Tang S, Zhai H, et al. Studies on anti-tumor metastatic constituents from Ardisia Crenata. Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(7):881-5. PMID: 21761727.

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