PIK-93 is an inhibitor of PI3K that exhibits some selectivity for p110α and p110γ. PIK-93 also inhibits PI4KIIIβ, a phosphatidylinositol enzyme similar to PI3K. PIK-93 decreases translocation of transient receptor potential canonical 6 channel (TRPC6) to the plasma membrane in vitro and may alter Ca2+ signaling as a result.
| Cas No. | 593960-11-3 |
|---|---|
| Purity | ≥98% |
| Formula | C14H16ClN3O4S2 |
| Formula Wt. | 389.88 |
| IUPAC Name | N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide |
| Synonym | PIK93 |
| Solubility | DMSO 78 mg/mL (200.06 mM) Water Insoluble Ethanol Insoluble |
| Appearance | Off-white Powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Monet M, Francoeur N, Boulay G. Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells. J Biol Chem. 2012 May 18;287(21):17672-81. PMID: 22493444.
