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Kb NB 142-70 is an inhibitor of PKD that is used to study PKD activity in research models. Kb NB 142-70 prevents angiotensin II-induced phosphorylation of histone deacetylases and increases activation of Akt in intestinal epithelial cells. This compound may also inhibit migration of intestinal epithelial cells.
| Cas No. | 1233533-04-4 |
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| Purity | ≥98% |
| Formula | C11H9NO2S2 |
| Formula Wt. | 251.32 |
| Chemical Name | 9-Hydroxy-3,4-dihydro-2H-[1]benzothiolo[2,3-f][1,4]thiazepin-5-one |
| IUPAC Name | 9-Hydroxy-3,4-dihydro[1]benzothieno[2,3-f][1,4]thiazepin-5(2H)-one |
| Synonym | Kb-NB142-70; 3,4-Dihydro-9-hydroxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(2H)-one; CHEMBL1672571 |
| Solubility | DMSO 100mM |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
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| Info Sheet |
Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541.
Ni Y, Sinnett-Smith J, Young SH, et al. PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One. 2013 Sep 9;8(9):e73149. Erratum in: PLoS One. 2014;9(1). PMID: 24039875.
Young SH, Rozengurt N, Sinnett-Smith J, et al. Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G356-66. PMID: 22595992.
