• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Silymarin

Silymarin

Product ID S3345
Cas No. 65666-07-1
Purity ≥50% sylibin
Product Unit SizeCostQuantityStock
10 g $61.00 In stock
50 g $172.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Silymarin is a flavonolignan mixture found in Silybum (milk thistle) seeds; it exhibits antiviral, anti-inflammatory, anti-fibrotic, hepatoprotective, neuroprotective, immunosuppressive, antioxidative, and anticancer activities. Silymarin inhibits influenza virus proliferation by suppressing viral RNA synthesis. In animal models of benign prostatic hyperplasia (BPH), silymarin decreases inflammation, collagen deposition, and levels of iNOS, COX-2, NF-κB, IL-6, IL-8, and HIF-1α. In animal models of fibrosis, silymarin decreases oxidative stress, fibrosis development, and levels of α-SMA and TGF-β1. Silymarin shows potential benefit in models of Parkinson’s disease and Alzheimer’s disease, inhibiting aggregation of proteins such as amyloid-β (Aβ). In activated T cells, silymarin induces G1 phase cell cycle arrest and decreases mTOR signaling. This compound decreases lipid peroxidation and increases radical scavenging and levels of glutathione in vivo. In ovarian cancer cells, silymarin increases expression of PTEN, decreases signaling by Akt and expression of Bcl-2, induces apoptosis, and inhibits cellular proliferation; it also inhibits telomerase activity.

Product Info

Cas No.

65666-07-1

Purity

≥50% sylibin

Formula

C25H22O10

Formula Wt.

482.44

IUPAC Name

(2S)-3,5,7-trihydroxy-2-[(2S, 3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1, 4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one

Synonym

Apihepar, Laragon, Legalon, Pluropon, Silarine, Silliver

Solubility

Soluble in DMSO or ethanol.

Appearance

Yellowish Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S3345 MSDS PDF

Info Sheet

S3345 Info Sheet PDF

References

Sato M, Murakami K, Uno M, et al. Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid-beta aggregation. Biosci Biotechnol Biochem. 2013;77(5):1100-1103. PMID: 23649236.

Atawia RT, Mosli HH, Tadros MG, et al. Modulatory effect of silymarin on inflammatory mediators in experimentally induced benign prostatic hyperplasia: emphasis on PTEN, HIF-1α, and NF-κB. Naunyn Schmiedebergs Arch Pharmacol. 2014 Aug 28. [Epub ahead of print]. PMID: 25164963

Clichici S, Olteanu D, Nagy AL, et al. Silymarin Inhibits the Progression of Fibrosis in the Early Stages of Liver Injury in CCl4-Treated Rats. J Med Food. 2014 Aug 18. [Epub ahead of print]. PMID: 25133972.

Borah A, Paul R, Choudhury S, et al. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. CNS Neurosci Ther. 2013 Nov;19(11):847-53. PMID: 24118806.

Su CH, Chen LJ, Liao JF, et al. Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. J Med Food. 2013 Sep;16(9):778-84. PMID: 23909904.

Kwon do Y, Jung YS, Kim SJ, et al. Alterations in sulfur amino acid metabolism in mice treated with silymarin: a novel mechanism of its action involved in enhancement of the antioxidant defense in liver. Planta Med. 2013 Aug;79(12):997-1002. PMID: 23807810.

Gharagozloo M, Javid EN, Rezaei A, et al. Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. Basic Clin Pharmacol Toxicol. 2013 Apr;112(4):251-6. PMID: 23121838.

Faezizadeh Z, Mesbah-Namin SA, Allameh A. The effect of silymarin on telomerase activity in the human leukemia cell line K562. Planta Med. 2012 Jun;78(9):899-902. PMID: 22532022.

Song JH, Choi HJ. Silymarin efficacy against influenza A virus replication. Phytomedicine. 2011 Jul 15;18(10):832-5. PMID: 21377857.

Murata N, Murakami K, Ozawa Y, et al. Silymarin attenuated the amyloid beta plaque burden and improved behavorial abnormalities in an Alzheimer’s disease mouse model. Biosci Biotechnol Biochem. 2010;74(11):2299-2306. PMID: 21071836.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A9803

    Azathioprine

    Purine nucleotide analog, mercaptiopurine prodr...

    ≥98%
  • D1849

    4′-Demethylepipodophyllotoxin

    Podophyllotoxin derivative found in Podophyllum...

    ≥98%
  • P0346

    Palosuran Hydrochloride

    Urotensin II receptor antagonist.
  • D1621

    Deferasirox

    Iron chelator.

    ≥99%
  • M568270

    Mogroside V

    Triterpenoid

    ≥98%
  • B4514

    Bleomycin A5 Hydrochloride Cu

    Induces apoptosis, DNA cleavage and strand brea...

    ≥85%
  • C9711

    Cyclovirobuxine D

    Found in Buxus; hERG K+ channel inhibitor.

    ≥97%
  • A0777

    ABT-263

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥99%
  • N8277

    Nutlin-3

    Imidzoline derivative; MDM2 inhibitor.

    ≥95%
  • R3321

    Rifaximin

    Rifampicin derivative; DNA-dependent RNA polyme...

    ≥98%
  • P691320

    PRI-724

    Wnt/beta-catenin/CBP inhibitor

    ≥98%
  • E544766

    Enterocin

    A bacteriocin

    ≥95%
  • M3598

    Mizoribine Hydrobromide

    IMPDH inhibitor.

    ≥98%
  • C9608

    Cycloastragenol

    Triterpene aglycone found in Radix Astragali; t...

    ≥98%
  • B1545

    Benzalkonium Bromide

    Quaternary ammonium cationic surfactant, dissoc...

    ≥95%
  • F8147

    Fulvestrant

    Induces ER degradation.

    ≥98%
  • G3455

    Ginsenoside Rc

    Triterpene saponin found in species of Panax; A...

    ≥98%
  • H9763

    Hypoxanthine

    Endogenous purine derivative of xanthine.

    ≥98%
  • P4008

    PKC412

    Staurosporine derivative; PKC and FLT3 inhibito...

    ≥98%
  • B3278

    Biotin

    Water-soluble coenzyme, vitamin (B7) found in v...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only