LKT Labs

Biochemicals for Life Science Research

Mogroside V

Product ID M568270
Cas No. 88901-36-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $109.00 In stock
25 mg $310.70 In stock
100 mg $953.80 In stock
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Description

Mogroside V is a triterpenoid isolated from the traditional Chinese medicinal plant Siraitia grosvenorii. Because of its intense sweetness, mogroside V is commonly used as a natural sweetener. It inhibits pancreatic tumor growth in in vitro and in vivo tumor models. It promotes apoptosis and cell cycle arrest of pancreatic cancer cells (pANC-1 cells). It was also found to inhibit angiogenesis and reduce vascular density in tumor growth. It has potent anti-inflammatory activity by inhibiting LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylationofKT1 I RAW264.7 cells.

Product Info

Cas No.

88901-36-4
Purity

≥98%
Formula

C60H102O29
Formula Wt.

1287.4
Chemical Name

Mogrol-3-O-(beta-D-glucopyranosyl (1-6)-beta-D-glucopyranoside)-24-O-((beta-D-glucopyranosyl (1-2))-(beta-D-glucopyranosyl(1-6))-beta-D-glucopyranoside)
IUPAC Name

(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6R)-6-[[(3S,8S,9R,10R,11R,13R,14S,17R)-17-[(2R,5R)-5-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-6-hydroxy-6-methylheptan-2-yl]-11-hydroxy-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
Synonym

Mogrol-3-O-(beta-D-glucopyranosyl (1-6)-beta-D-glucopyranoside)-24-O-((beta-D-glucopyranosyl (1-2))-(beta-D-glucopyranosyl(1-6))-beta-D-glucopyranoside); mogroside-V

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

M568270 MSDS PDF
Info Sheet

M568270 Info Sheet PDF

References

C Liu, L-H Dai, D-Q Dou., et al. A natural food sweetener with anti-pancreatic cancer properties. Oncogenesis. 2016, 5(4). PMID: 27065453 DOI: 10.1038/oncsis.2016.28.

Yong Li, Luyan Zou, Tao Li. et.al. Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells. Acta Biochim Biophys Sin (Shanghai). 2019 ;51(4):365-374. PMID: 30877761 DOI:10.1093/abbs/gmz014.

Xiao R, Liao W, Luo G, et al. Modulation of gut microbiota composition and short-chain fatty acid synthesis by mogroside V in an in vitro incubation system. ACS Omega. 2021 Sep 21;6(39):25486-25496. PMID: 34632206.

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