Mogroside V is a triterpenoid isolated from the traditional Chinese medicinal plant Siraitia grosvenorii. Because of its intense sweetness, mogroside V is commonly used as a natural sweetener. It inhibits pancreatic tumor growth in in vitro and in vivo tumor models. It promotes apoptosis and cell cycle arrest of pancreatic cancer cells (pANC-1 cells). It was also found to inhibit angiogenesis and reduce vascular density in tumor growth. It has potent anti-inflammatory activity by inhibiting LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylationofKT1 I RAW264.7 cells.