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AMG-232

Product ID A488246
Cas No. 1352066-68-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $85.00 In stock
5 mg $175.00 In stock
10 mg $305.00 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

AMG-232 is an inhibitor of the p53-MDM2 protein-protein interaction.
Studies on a mouse model resulted in activated p53 signaling and inhibited growth of various tumor xenografts. AMG-232 was shown to block DNA synthesis and induce apoptosis in vivo.

Product Info

Cas No.

1352066-68-2

Purity

≥99%

Formula

C28H35Cl2NO5S

Formula Wt.

568.55

IUPAC Name

2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-3-methyl-1-propan-2-ylsulfonylbutan-2-yl]-2-oxopiperidin-3-yl]acetic acid

Synonym

Navtemadlin

Appearance

White crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

A488246 Info Sheet PDF

References

Ye Q, Jiang M, Huang W, et al. Pharmacokinetics and metabolism of AMG-232, a novel bioavailable inhibitor of the MDM2-p53 interaction, in rats, dogs and monkeys: in vitro-in vivo correlation. Xenobiotica. 2015;45(8):681-692. PMID: 25798742

Canon J, Osgood T, Olson S, et al. The MDM2 inhibitor AMG 232 demonstrates robust antitumor efficacy and potentiates the activity of p53-inducing cytotoxic agents. Mol Cancer Ther. 2015 Mar;14(3):649-658. PMID: 25567130

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