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Tenovin-1

Product ID T1852
Cas No. 380315-80-0
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $86.40 In stock
25 mg $172.80 In stock
100 mg $540.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tenovin-1 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-1 exhibits anticancer potential, increasing FOXO3 and p53 expression and inducing apoptosis in cutaneous T-cell lymphoma cells.

Product Info

Cas No.

380315-80-0

Purity

≥98%

Formula

C20H23N3O2S

Formula Wt.

369.48

Chemical Name

N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

IUPAC Name

N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

Synonym

N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

Solubility

DMSO 74 mg/mL (200.28 mM) Water Insoluble Ethanol Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T1852 MSDS PDF

Info Sheet

T1852 Info Sheet PDF

References

Nihal M, Ahmad N, Wood GS. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell Cycle. 2014 Feb 15;13(4):632-40. PMID: 24343700.

Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.

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