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Piroxicam

Product ID P3269
Cas No. 36322-90-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $51.90 In stock
5 g $129.80 In stock
10 g $246.70 In stock
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  • Product Info
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  • Description
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Description

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, antipyretic, neuroprotective, anticancer, and chemopreventive activities. Piroxicam inhibits COX-1 and COX-2. Cu(II) complexes of piroxicam bind GC sequences of DNA. In animal models, this compound decreases development of polyps and colorectal cancer. In cellular models of Parkinson’s disease, piroxicam inhibits MPP+-induced decreases in phosphorylated Akt and neurodegeneration.

Product Info

Cas No.

36322-90-4

Purity

≥98%

Formula

C15H13N3O4S

Formula Wt.

331.35

Chemical Name

4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2- benzothiazine-3-carboxamide-1,1-dioxide

IUPAC Name

4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-1λ6, 2-benzothiazine-3-carboxamide

Synonym

Feldene, Piroftal, Roxicam

Melting Point

198-200°C

Solubility

Insoluble in water. Soluble in acetonitrile.

Appearance

Off-White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P3269 MSDS PDF

Info Sheet

P3269 Info Sheet PDF

Brochures

NSAID Flyer

References

Chakraborty S, Bose M, Sarkar M. Spectroscopic studies of the binding of Cu(II) complexes of oxicam NSAIDs to alternating G-C and homopolymeric G-C sequences. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Mar 25;122:690-7. PMID: 24345609.

Barkin RL. Topical Nonsteroidal Anti-Inflammatory Drugs: The Importance of Drug, Delivery, and Therapeutic Outcome. Am J Ther. 2012 Feb 22. [Epub ahead of print]. PMID: 22367354.

Tasaki Y, Yamamoto J, Omura T, et al. Oxicam structure in non-steroidal anti-inflammatory drugs is essential to exhibit Akt-mediated neuroprotection against 1-methyl-4-phenyl pyridinium-induced cytotoxicity. Eur J Pharmacol. 2012 Feb 15;676(1-3):57-63. PMID: 22182582.

Qiu ZF, Maruyama K, Sunayama K, et al. Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice. J Invest Surg. 2003 Mar-Apr;16(2):71-81. PMID: 12746190.

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