LKT Labs

Biochemicals for Life Science Research

Aliskiren Hemifumarate

Product ID A4534
Cas No. 173334-58-2
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $83.40 In stock
100 mg $222.50 In stock
250 mg $370.40 In stock
Bulk Quote

Quicklinks

Description

Aliskiren is a direct renin inhibitor that exhibits antihypertensive, antithrombotic, and anti-angiogenic activities. Aliskiren binds to the S3bp binding site of renin, inhibiting its ability to cleave angiotensinin into angiotensin I, therefore preventing the formation of angiotensin II and resulting contraction of arterial smooth muscle. This compound is a vasodilator, decreasing plasma volume and blood pressure in vivo. In animal models of lupus nephritis, aliskiren attenuated proteinuria by decreasing inflammatory cytokine levels and glomerular inflammation. Additionally, in separate animal studies, aliskiren decreases VEGF levels, improves insulin resistance, and prevents development of venous thrombosis.

Product Info

Cas No.

173334-58-2
Purity

≥98%
Formula

(C30H53N3O6)2 • C4H4O4
Formula Wt.

1219.59
Chemical Name

(2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide hemifumarate
IUPAC Name

(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide;(E)-but-2-enedioic acid
Solubility

Soluble in water (≥122 mg/mL), ethanol ≥122 mg/mL), and DMSO (≥122 mg/mL).
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A4534 MSDS PDF
Info Sheet

A4534 Info Sheet PDF

References

Yen TH, Yang HY, Yeh YH, et al. Aliskiren attenuates proteinuria in mice with lupus nephritis by a blood pressure-independent mechanism. Lupus. 2013 Feb;22(2):180-9. PMID: 23257405.

Hermanowicz JM, Hermanowicz A, Buczko P, et al. Aliskiren inhibits experimental venous thrombosis in two-kidney one- clip hypertensive rats. Thromb Res. 2013 Jan;131(1):e39-44. PMID: 23174623.

Gandhi S, Srinivasan B, Akarte AS. Aliskiren improves insulin resistance and ameliorates diabetic renal vascular complications in STZ-induced diabetic rats. J Renin Angiotensin Aldosterone Syst. 2013 Mar;14(1):3-13. PMID: 22791702.

Kühnast S, van der Hoorn JW, van den Hoek AM, et al. Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin. J Hypertens. 2012 Jan;30(1):107-16. PMID: 22134386.

Buczko W, Hermanowicz JM. Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor. Pharmacol Rep. 2008 Sep-Oct;60(5):623-31. PMID: 19066408.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.