Fenticonazole Nitrate

Name: Fenticonazole Nitrate
SKU: F1854
Availability: InStock

Product ID F1854

Cas No. 73151-29-8

Purity ≥98%

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Description

Fenticonazole is an imidazole derivative that exhibits antifungal, antibacterial, and anti-parasitic activities. Fenticonazole inhibits secretion of proteinase, potentially through antagonism of glucosamine-6-phosphate synthase; it also damages fungal cytoplasmic membranes and inhibits cytochrome oxidases and peroxidases. Fenticonazole displays antimicrobial activity against a variety of organisms, including species of Candida, Trichomonas, and gram positive bacteria. This compound may inhibit 14-α demethylase.

Product Info

Cas No.	73151-29-8
Purity	≥98%
Formula	C₂₄H₂₀Cl₂N₂OS • HNO₃
Formula Wt.	518.41
IUPAC Name	1-[2-(2, 4-dichlorophenyl)-2-[(4-phenylsulfanylphenyl)methoxy]ethyl]imidazole; nitric acid
Melting Point	136°C
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	F1854 MSDS PDF
Info Sheet	F1854 Info Sheet PDF

References

Veraldi S, Milani R. Topical fenticonazole in dermatology and gynaecology: current role in therapy. Drugs. 2008;68(15):2183-94. PMID: 18840006.

Fernández-Alba J, Valle-Gay A, Dibildox M, et al. Fenticonazole nitrate for treatment of vulvovaginitis: efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen. J Chemother. 2004 Apr;16(2):179-86. PMID: 15216954.

Palacín C, Tarragó C, Agut J, et al. In vitro activity of sertaconazole, fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole against pathogenic vaginal yeast isolates. Methods Find Exp Clin Pharmacol. 2001 Mar;23(2):61-4. PMID: 11484411.

Milewski S, Mignini F, Covelli I, et al. Specific inhibition of acid proteinase secretion in Candida albicans by Lys-Nva-FMDP. J Med Vet Mycol. 1994;32(1):1-11. PMID: 8207618.

Graziani G, Cazzulani P. Irritation and toxicity studies with fenticonazole applied topically to the skin and mucous membranes. Arzneimittelforschung. 1981;31(12):2152-4. PMID: 7199317.