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Ziconotide in an ω-conopeptide originally isolated from the venom of a marine snail. Ziconotide has been shown to prevent neuronal damage resulting from cerebral ischemia in Fischer-344 rats. Furthermore, ziconotide is a selective N-type calcium channel blocker, non-opioid analgesic.
| Cas No. | 107452-89-1 |
|---|---|
| Purity | ≥95% |
| Formula | C102H172N36O32S7 |
| Formula Wt. | 2639.16 |
| Synonym | ω-Conotoxin MVIIA, SNX-111 |
| Solubility | Soluble in 1% acetic acid (1 mg/mL), water, PBS. |
| Appearance | White powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Valentino K, Newcomb R, Badbois T, et al. A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia. Proc Natl Acad Sci USA. 1993 Aug 15;90(16):7894-7897. PMID: 8102803.
Pringle AK, Benham CD, Sim L, et al. Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal-slice cultures. Stroke. 1996 Nov;27(11):2124-2130. PMID: 8898826.
Berman RF, Verweij BH, Muizelaar JP. Neurobehavioral protection by the neuronal calcium channel blocker ziconotide in a model of traumatic diffuse brain injury in rats. J Neurosurg. 2000 Nov;93(5):821-828. PMID: 11059664.
Pope JE, Deer TR, Bruel BM, et al. Clinical uses of intrathecal therapy and its placement in the pain care algorithm. Pain Pract. 2016 Feb 23. doi:10.1111/papr.12438. PMID: 26914961.
