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6-Gingerol

Product ID G3252
Cas No. 23513-14-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $162.00 In stock
25 mg $570.50 In stock
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Description

6-Gingerol is originally found in species of Zingiber; it that exhibits antiemetic, antacid, anticancer, anti-inflammatory, anti-obesity, antihypertensive, anti-asthma, analgesic, and antinociceptive activities. 6-Gingerol inhibits 5-HT3 receptors and K2P 3.1 (TASK-1), K2P 9.1 (TASK-3), and K2P 18.1 (TRESK) K+ channels. 6-Gingerol also activates transient receptor potential vanilloid 1 (TRPV1) channels, decreasing allodynia and hyperalgesia in vivo. In other models, 6-gingerol inhibits the angiotensin II type 1 (AT-II) receptor, decreasing blood pressure. This compound also induces G2/M phase cell cycle arrest and apoptosis, inhibits mitochondrial respiration, increases oxidative stress and ROS production, and inhibits proliferation in myeloid leukemia cells. Additionally, 6-gingerol inhibits IL-1β-induced production of COX-2, NF-κB, IL-6, and IL-8, suppressing hepatic inflammation in vitro. 6-gingerol also inhibits rosiglitazone-induced adipogenesis, decreasing triglyceride levels and oil droplet sizes and downregulating expression of PPARγ. This compound also attenuates airway hyperresponsiveness in animal models.

Product Info

Cas No.

23513-14-6

Purity

≥98%

Formula

C17H26O4

Formula Wt.

294.39

IUPAC Name

(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one

Solubility

Soluble in ethanol, benzene, ether, chloroform, methanol (1 mg/ml), and DMSO. Insoluble in water

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G3252 MSDS PDF

Info Sheet

G3252 Info Sheet PDF

References

Jin Z, Lee G, Kim S, et al. Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons. Korean J Physiol Pharmacol. 2014 Apr;18(2):149-53. PMID: 24757377.

Rastogi N, Gara RK, Trivedi R, et al. (6)-Gingerolinduced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression. Free Radic Biol Med. 2014 Mar;68:288-301. PMID: 24378438.

Tzeng TF, Chang CJ, Liu IM. 6-gingerol inhibits rosiglitazone-induced adipogenesis in 3T3-L1 adipocytes. Phytother Res. 2014 Feb;28(2):187-92. PMID: 23519881.

Beltrán LR, Dawid C, Beltrán M, et al. The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK. Front Pharmacol. 2013 Nov 18;4:141. PMID: 24302912.

Li XH, McGrath KC, Tran VH, et al. Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells. Evid Based Complement Alternat Med. 2013;2013:146142. PMID: 23843863.

Gauthier ML, Beaudry F, Vachon P. Intrathecal [6]-gingerol administration alleviates peripherally induced neuropathic pain in male Sprague-Dawley rats. Phytother Res. 2013 Aug;27(8):1251-4. PMID: 22972597.

Liu Q, Liu J, Guo H, et al. [6]-gingerol: a novel AT₁ antagonist for the treatment of cardiovascular disease. Planta Med. 2013 Mar;79(5):322-6. PMID: 23479389.

Townsend EA, Siviski ME, Zhang Y, et al. Effects of ginger and its constituents on airway smooth muscle relaxation and calcium regulation. Am J Respir Cell Mol Biol. 2013 Feb;48(2):157-63. PMID: 23065130.

Okumi H, Tashima K, Matsumoto K, et al. Dietary agonists of TRPV1 inhibit gastric acid secretion in mice. Planta Med. 2012 Nov;78(17):1801-6. PMID: 23047250.

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