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Phallicidin is a phallotoxin found in Amanita phalloides that exhibits cytotoxic activity. Phallicidin binds F-actin and inhibits depolymerization; it locks adjacent subunits together, preventing actin ATP hydrolysis. Fluorescent-tagged conjugates of phallicidin are used to measure distribution of F-actin in vitro. Phallicidin also inhibits mast cell degranulation.
| Cas No. | 26645-35-2 |
|---|---|
| Purity | ≥98% |
| Formula | C37H50N8O13S |
| Formula Wt. | 846.91 |
| Chemical Name | cyclic(L-Alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl-L-valyl-erythro-3-hydroxy-D-alpha-aspartyl-L-cysteinyl-cis-4-hydroxy-L-prolyl) cyclic (2-6)-sulfide |
| Synonym | Falacidin |
| Solubility | Soluble in DMSO, methanol, water or dimethyl formamide. |
| Appearance | White powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Schmid E, Gu S, Yang W, et al. Serum- and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation. Am J Physiol Cell Physiol. 2013 Jan 1;304(1):C49-55. PMID: 23015548.
Zalavary S, Bengtsson T. Adenosine inhibits actin dynamics in human neutrophils: evidence for the involvement of cAMP. Eur J Cell Biol. 1998 Feb;75(2):128-39. PMID: 9548370.
