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Phallacidin

Phallacidin

Product ID P2303
Cas No. 26645-35-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $510.50 In stock
5 mg $1,823.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Phallicidin is a phallotoxin found in Amanita phalloides that exhibits cytotoxic activity. Phallicidin binds F-actin and inhibits depolymerization; it locks adjacent subunits together, preventing actin ATP hydrolysis. Fluorescent-tagged conjugates of phallicidin are used to measure distribution of F-actin in vitro. Phallicidin also inhibits mast cell degranulation.

Product Info

Cas No.

26645-35-2

Purity

≥98%

Formula

C37H50N8O13S

Formula Wt.

846.91

Chemical Name

cyclic(L-Alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl-L-valyl-erythro-3-hydroxy-D-alpha-aspartyl-L-cysteinyl-cis-4-hydroxy-L-prolyl) cyclic (2-6)-sulfide

IUPAC Name

2-[28-(2,3-dihydroxy-2-methylpropyl)-18-hydroxy-23-methyl-15,21,24,26,29,32,35-heptaoxo-31-propan-2-yl-12-thia-10,16,22,25,27,30,33,36-octazapentacyclo[12.11.11.03,11.04,9.016,20]hexatriaconta-3(11),4,6,8-tetraen-34-yl]-2-hydroxyacetic acid

Synonym

Falacidin

Solubility

Soluble in DMSO, methanol, water or dimethyl formamide.

Appearance

White powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P2303 MSDS PDF

Info Sheet

P2303 Info Sheet PDF

References

Schmid E, Gu S, Yang W, et al. Serum- and glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation. Am J Physiol Cell Physiol. 2013 Jan 1;304(1):C49-55. PMID: 23015548.

Zalavary S, Bengtsson T. Adenosine inhibits actin dynamics in human neutrophils: evidence for the involvement of cAMP. Eur J Cell Biol. 1998 Feb;75(2):128-39. PMID: 9548370.

Custom Order

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