BVT-2733

Name: BVT-2733
SKU: B8676
Availability: InStock

Product ID B8676

Cas No. 376640-41-4

Purity ≥98%

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Product Info
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References

Description

BVT-2733 is an inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) that exhibits anti-diabetic, anti-inflammatory, and anti-osteoporotic properties. BVT-2733 decreases blood glucose and serum insulin levels in animal models of hyperglycemia. BVT-2733 also attenuates arthritis severity, decreases pro-inflammatory cytokine production, and suppresses synovial inflammation. In other animal models, this compound prevents 11βHSD-induced osteogenic differentiation and suppression of osteogenesis.

Product Info

Cas No.	376640-41-4
Purity	≥98%
Formula	C₁₇H₂₁ClN₄O₃S₂
Formula Wt.	428.96
Chemical Name	3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide
IUPAC Name	3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide
Synonym	BVT2733
Solubility	40mg/ml in DMSO

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	B8676 MSDS PDF
Info Sheet	B8676 Info Sheet PDF

References

Zhang L, Dong Y, Zou F, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94. PMID: 23938253.

Wu L, Qi H, Zhong Y, et al. 11β-Hydroxysteroid dehydrogenase type 1 selective inhibitor BVT.2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction. Endocr J. 2013;60(9):1047-58. PMID: 23759754.

Alberts P, Engblom L, Edling N, et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia. 2002 Nov;45(11):1528-32. PMID: 12436336.