LKT Labs

Biochemicals for Life Science Research

BVT-2733

BVT-2733

Product ID B8676
Cas No. 376640-41-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $118.00 In stock
25 mg $481.20 In stock
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Description

BVT-2733 is an inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) that exhibits anti-diabetic, anti-inflammatory, and anti-osteoporotic properties. BVT-2733 decreases blood glucose and serum insulin levels in animal models of hyperglycemia. BVT-2733 also attenuates arthritis severity, decreases pro-inflammatory cytokine production, and suppresses synovial inflammation. In other animal models, this compound prevents 11βHSD-induced osteogenic differentiation and suppression of osteogenesis.

Product Info

Cas No.

376640-41-4
Purity

≥98%
Formula

C17H21ClN4O3S2
Formula Wt.

428.96
Chemical Name

3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide
IUPAC Name

3-Chloro-2-methyl-N-{4-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1,3-thiazol-2-yl}benzenesulfonamide
Synonym

BVT2733
Solubility

40mg/ml in DMSO

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B8676 MSDS PDF
Info Sheet

B8676 Info Sheet PDF

References

Zhang L, Dong Y, Zou F, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94. PMID: 23938253.

Wu L, Qi H, Zhong Y, et al. 11β-Hydroxysteroid dehydrogenase type 1 selective inhibitor BVT.2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction. Endocr J. 2013;60(9):1047-58. PMID: 23759754.

Alberts P, Engblom L, Edling N, et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia. 2002 Nov;45(11):1528-32. PMID: 12436336.

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