• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Diclofenac Impurity B

Diclofenac Impurity B

Product ID D324096
Cas No. 22121-58-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.30 In stock
25 mg $227.10 In stock
100 mg $584.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Diclofenac Impurity B is an impurity of diclofenac.

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that is clinically used to treat inflammation associated with arthritis and gout as well as other pain or inflammatory disorders; it is somewhat selective in inhibiting COX-2 over COX-1. Diclofenac exhibits anti-inflammatory, antipyretic, analgesic, antinociceptive, anticonvulsant, anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In vitro, the anticonvulsant/antiepileptic activity of diclofenac may stem from inhibition of delayed rectifier K+ channel amplitude and acceleration of channel inactivation; it also increases the amplitude of M-type K+ channels. This compound inhibits DMH-induced colon carcinogenesis in vivo, decreasing levels of COX-2, VEGF, and MCP-1. Diclofenac also decreases the epithelial-to-mesenchymal transition (EMT), suppressing squamous cell carcinoma tumor growth.

Product Info

Cas No.

22121-58-0

Purity

≥98%

Formula

C13H9Cl2NO

Formula Wt.

266.12

Chemical Name

2-[(2,6-Dichlorophenyl)amino]benzaldehyde

IUPAC Name

2-[(2,6-Dichlorophenyl)amino]benzaldehyde

Synonym

Diclofenac impurity 2, 2-(2,6-Dichloroanilino)benzaldehyde, 2-[(2,6-Dichlorophenyl)amino]benzaldehyde, N-(2,6-Dichlorophenyl)anthranilaldehyde, MFCD03788574

Melting Point

112-114°C

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D324096 MSDS PDF

Info Sheet

D324096 Info Sheet PDF

References

Giordano, F., Rossi, A., Pasquali, I. et al. Thermal degradation and melting point determination of diclofenac. Journal of Thermal Analysis and Calorimetry 73, 509–518 (2003). https://doi.org/10.1023/A:1025421911670

Arumugam A, Weng Z, Talwelkar SS, et al. Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. PLoS One. 2013 Nov 8;8(11):e80076. PMID: 24260338.

Akbari E, Mirzaei E, Shahabi Majd N. Long-term Morphine-treated Rats are more Sensitive to Antinociceptive Effect of Diclofenac than the Morphine-naive rats. Iran J Pharm Res. 2013 Winter;12(1):175-84. PMID: 24250586.

Huang CW, Hung TY, Liao YK, et al. Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study. J Physiol Pharmacol. 2013 Jun;64(3):269-80. PMID: 23959723.

Kaur J, Sanyal SN. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1α and VEGF. Mol Carcinog. 2011 Sep;50(9):707-18. PMID: 21268133.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B5728

    Bohemine

    Purine derivative; CDK inhibitor.

    ≥98%
  • B3211

    (+)-Bicuculline

    NMDA potentiator, GABA-A antagonist.

    ≥98%
  • A7460

    Asparaginase

    Catalyzes hydrolysis of asparagine.

    ≥98%
  • G0179

    Gastrin-1, rat

    Endogenous peptide hormone; CCK2 agonist, indir...

    ≥95%
  • C5654

    Concanavalin A

    Lectin found in Canavelia, plant mitogen that b...

  • I7357

    Isorhamnetin

    Flavonol found in Tagetes.

    ≥98%
  • C281006

    Chaetocin

    Chaetocin is naturally produced by Chaetomium s...

    ≥98%
  • B6998

    Bryostatin 1

    Macrolide lactone found in Bugula; TLR4 activat...

    ≥98%
  • P3563

    Piperlonguminine

    Found in Piper longum.

    ≥99%
  • M0173

    Mastoparan X

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • N1858

    Neosolaniol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • S0929

    SCH-772984

    ERK1/2 inhibitor.

    ≥97%
  • A0099

    A-779

    Mas antagonist.

    ≥95%
  • D3214

    2′,3′-Dideoxyinosine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • A6932

    Aristolochic Acid A

    Found in Aristolochia and Radix; PLA2 inhibitor...

    ≥95%
  • C5645

    Colchicine

    Found in Colchicum; microtubule polymerization ...

    ≥97%
  • K0038

    Kahweol Oleate

    Diterpene found in coffee beans.

    ≥98%
  • SB5776

    Snake venom – Bothrops alternatus (urutu)

    Snake venom found in Bothrops alternatus urutu....

    ≥98%
  • A1318

    Adenine

    Endogenous purine nucleotide base, required for...

    ≥98%
  • C2800

    Chalcone

    Enone.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only