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Mastoparan X is an antimicrobial/antibacterial peptide (AMP) derived from the venom of bees and wasps. Mastoparan X activates mast cells through binding and activation of the Gα subunit of GPCRs. Mastoparan X enters into neutral and negatively charged membranes, causing formation and leakage of giant unilamellar vesicles and inducing barrier disruptions.
| Cas No. | 72093-22-2 |
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| Purity | ≥95% |
| Formula | C73H126N20O15S |
| Formula Wt. | 1556.01 |
| IUPAC Name | (2S)-N-[(2S)-1-[[(2S)-6-amino-1-[[2-[[(3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]butanediamide |
| Synonym | Mast cell degranulating peptide (Vespa xanthoptera) (9CI) |
| Solubility | Soluble in water (1 mg/mL). |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
dos Santos LD, Aparecido dos Santos Pinto JR, Menegasso AR, et al. Proteomic profiling of the molecular targets of interactions of the mastoparan peptide Protopolybia MP-III at the level of endosomal membranes from rat mast cells. Proteomics. 2012 Aug;12(17):2682-93. PMID: 22761183.
Cabrera MP, Alvares DS, Leite NB, et al. New insight into the mechanism of action of wasp mastoparan peptides: lytic activity and clustering observed with giant vesicles. Langmuir. 2011 Sep 6;27(17):10805-13. PMID: 21797216.
Etzerodt T, Henriksen JR, Rasmussen P, et al. Selective acylation enhances membrane charge sensitivity of the antimicrobial peptide mastoparan-x. Biophys J. 2011 Jan 19;100(2):399-409. PMID: 21244836.
Todokoro Y, Yumen I, Fukushima K, et al. Structure of tightly membrane-bound mastoparan-X, a G-protein-activating peptide, determined by solid-state NMR. Biophys J. 2006 Aug 15;91(4):1368-79. PMID: 16714348.
