• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Palbociclib Hydrochloride

Palbociclib Hydrochloride

Product ID P0244
Cas No. 827022-32-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $45.30 In stock
5 mg $127.90 In stock
25 mg $375.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Palbociclib is an orally bioavailable selective inhibitor of CDK4 and CDK6, kinases that regulate cell cycle progression. This compound exhibits anticancer chemotherapeutic activity in a variety of models, including renal cell carcinoma and ER+ breast cancer. Palbociclib inhibits retinoblastoma phosphorylation, preventing cells from progressing from the G1 phase to the S phase and inducing apoptosis.

Product Info

Cas No.

827022-32-2

Purity

≥99%

Formula

C24H29N7O2 • HCl

Formula Wt.

483.99

IUPAC Name

6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one;hydrochloride

Synonym

PD-0332991

Solubility

Soluble in DMSO and water

Appearance

Yellow Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P0244 MSDS PDF

Info Sheet

P0244 Info Sheet PDF

References

Logan JE, Mostofizadeh N, Desai AJ, et al. PD-0332991, a Potent and Selective Inhibitor of Cyclin-dependent Kinase 4/6, Demonstrates Inhibition of Proliferation in Renal Cell Carcinoma at Nanomolar Concentrations and Molecular Markers Predict for Sensitivity. Anticancer Res. 2013 Aug;33(8):2997-3004. PMID: 23898052.

Roberts PJ, Bisi JE, Strum JC, et al. Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. J Natl Cancer Inst. 2012 Mar 21;104(6):476-87. PMID: 22302033.

Rivadeneira DB, Mayhew CN, Thangavel C, et al. Proliferative suppression by CDK4/6 inhibition: complex function of the retinoblastoma pathway in liver tissue and hepatoma cells. Gastroenterology. 2010 May;138(5):1920-30. PMID: 20100483.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5070

    Angiotensin Acetate

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • C9614

    Cyclosporin H

    Cyclosporin metabolite; formyl peptide inhibito...

    ≥96%
  • H9763

    Hypoxanthine

    Endogenous purine derivative of xanthine.

    ≥98%
  • O9398

    Oxymetazoline Hydrochloride

    Imidazoline derivative; α1-adrenergic agonist,...

    ≥98%
  • P6800

    Pravastatin Lactone

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • N1986

    Neuropeptide Y, human/rat

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • T3197

    L-Thyroxine Sodium Pentahydrate

    Endogenous thyroid hormone T4.

    ≥97%
  • N1977

    Neurokinin A (4-10)

    Endogenous neuropeptide, also known as substanc...

    ≥95%
  • P4403

    Plasminogen Activator Inhibitor 1

    Endogenous peptide, produced by activation of P...

    ≥95%
  • G0246

    Galantamine Hydrobromide

    Alkaloid found in Galanthus, Narcissus, Leucoju...

    ≥98%
  • M177531

    Menaquinone-9

    2-methyl-1,4-naphthoquinone derivative

    ≥99%
  • T2933

    4-Thiouridine

    Modified nucleotide used for labeling DNA; DNA ...

    ≥99%
  • R3584

    Rivaroxaban

    Oxazolidone derivative; Factor Xa inhibitor.

    ≥98%
  • D3374

    Disulfiram

    Aldehyde dehydrogenase, 26S proteasome, MGMT in...

    ≥98%
  • A7657

    Atosiban Acetate

    Peptide, alters uterine contractility; V1/2 and...

    ≥95%
  • C0367

    S-(−)-Carbidopa Monohydrate

    Hydrazine; L-amino acid decarboxylase inhibitor...

    ≥98%
  • D0005

    Dabrafenib Mesylate

    B-Raf and c-Raf inhibitor.

    ≥98%
  • S176481

    Semaglutide

    GLP-1 agonist

    ≥95%
  • G1849

    Gemifloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • O9596

    Oxybutynin Hydrochloride

    mAChR antagonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only