Quinapril Hydrochloride

Name: Quinapril Hydrochloride
SKU: Q8134
Availability: InStock

Product ID Q8134

Cas No. 82586-55-8

Purity ≥98%

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Description
Product Info
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Description

Quinapril is an angiotensin II-converting enzyme (ACE) inhibitor that exhibits antihypertensive, anti-inflammatory, and cardioprotective activities; it is clinically used to treat hypertension and congestive heart failure. Quinapril decreases levels of aldosterone and increases excretion of Na+. In animal models, quinapril decreases activity of matrix metalloproteinase 2 (MMP2), suppressing left ventricular remodeling. Additionally, this compound decreases expression of pro-inflammatory cytokines in animal models of heart failure.

Product Info

Cas No.	82586-55-8
Purity	≥98%
Formula	C₂₅H₃₀N₂O₅ • HCl
Formula Wt.	474.99
Chemical Name	(3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3- phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid hydrochloride
IUPAC Name	(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl] -3,4-dihydro-1H-isoquinoline-3-carboxylic acid;hydrochloride
Synonym	Accupril, Accuprin, Accupro, Acequin, Acuitel, Korec, Quinazil
Melting Point	120-130°C
Solubility	Soluble in water (31mg/mL).
Appearance	White crystalline powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	Q8134 MSDS PDF
Info Sheet	Q8134 Info Sheet PDF

References

Brower GL, Levick SP, Janicki JS. Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3057-64. PMID: 17308006.

We GC, Siroi MG, Qu R, et al. Effects of quinapril on myocardial function, ventricular remodeling and cardiac cytokine expression in congestive heart failure in the rat. Cardiovasc Drugs Ther. 2002 Jan;16(1):29-36. PMID: 12085975.