MDL 29951

Name: MDL 29951
SKU: M1444
Availability: InStock

Product ID M1444

Cas No. 130798-51-5

Purity ≥98%

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Description

MDL 29951 acts as an agonist at GPR17, inhibiting maturation of primary oligodendrocytes and potentially promoting myelin repair in models of multiple sclerosis. MDL 29951 also inhibits NMDA receptors at the glycine site as well as fructose 1,6-bisphosphatase. This compound displays neuromodulatory, anticonvulsant, and antinociceptive activities. In vivo, MDL 29951 inhibits formalin-induced licking. In animal models of seizures, this compound increases thresholds for the development of chemically-induced seizures.

Product Info

Cas No.	130798-51-5
Purity	≥98%
Formula	C₁₂H₉Cl₂NO₄
Formula Wt.	302.11
IUPAC Name	3-(2-Carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
Synonym	MDL29951
Solubility	10 mM in DMSO
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	M1444 MSDS PDF
Info Sheet	M1444 Info Sheet PDF

References

Hennen S, Wang H, Peters L, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013 Oct 22;6(298):ra93. PMID: 24150254.

Wright SW, Carlo AA, Danley DE, et al. 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid: an allosteric inhibitor of fructose-1,6-bisphosphatase at the AMP site. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2055-8. PMID: 12781194.

Millan MJ, Seguin L. Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice. Neurosci Lett. 1994 Aug 29;178(1):139-43. PMID: 7816323.

Baron BM, Harrison BL, McDonald IA, et al. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. J Pharmacol Exp Ther. 1992 Sep;262(3):947-56. PMID: 1388205.