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Mitoxantrone Dihydrochloride

Product ID M3379
Cas No. 70476-82-3
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $120.30 In stock
100 mg $204.50 In stock
500 mg $477.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mitoxantrone is an anthracenedione that exhibits immunosuppressive and anticancer chemotherapeutic activities. Mitoxantrone is clinically used to treat multiple sclerosis (MS), breast cancer, non-Hodgkin’s lymphoma, acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL). Mitoxantrone acts as an intercalator, cross-linking and forming complexes in DNA, inhibiting DNA synthesis; it also inhibits Pim-1 kinase.

Product Info

Cas No.

70476-82-3

Purity

≥98%

Formula

C22H28N4O6 • 2HCl

Formula Wt.

517.41

Chemical Name

1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl) amino]- ethyl] amino]-9,10-anthracenedione dihydrochloride

IUPAC Name

1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9, 10-dione;dihydrochloride

Synonym

Mitoxantrone hydrochloride, Novantrone

Melting Point

160-162°C

Solubility

Soluble in water, ethanol, DMSO.

Appearance

Blue/Black Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M3379 MSDS PDF

Info Sheet

M3379 Info Sheet PDF

References

Pendleton M, Lindsey RH Jr, Felix CA, et al. Topoisomerase II and leukemia. Ann N Y Acad Sci. 2014 Mar;1310:98-110. PMID: 24495080.

Wan X, Zhang W, Li L, et al. A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling. J Med Chem. 2013 Mar 28;56(6):2619-29. PMID: 23442188.

Parker C, Waters R, Leighton C, et al. Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. Lancet. 2010 Dec 11;376(9757):2009-17. PMID: 21131038.

Mazerski J, Martelli S, Borowski E. The geometry of intercalation complex of antitumor mitoxantrone and ametantrone with DNA: molecular dynamics simulations. Acta Biochim Pol. 1998;45(1):1-11. PMID: 9701490.

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