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Bexarotene

Product ID B1992
Cas No. 153559-49-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $64.90 In stock
100 mg $138.90 In stock
250 mg $296.30 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Bexarotene is a retinoid compound that binds and activates retinoid X receptors (RXRs) and is approved to treat cutaneous T cell lymphoma. Bexarotene displays a wide variety of beneficial activities, such as anticancer chemotherapeutic, anti-hyperlipidemic, and neuroprotective properties. Bexarotene has shown pre-clinical and clinical efficacy in treatment of other cancers, increasing apoptosis and inducing tumor regression in vitro and in vivo. Bexarotene’s activation of RXRs also results in activation of PPARα signaling, decreasing triglyceride levels and increasing HDL cholesterol levels in vivo. This compound interacts with nuclear hormone receptor Nurr1-RXR heterodimers, reversing behavioral deficits induced by 6-OH DA in rat models of Parkinson’s disease. Additionally, bexarotene activation of RXRs induces ApoE-dependent clearance of amyloid-β (Aβ) peptides and plaques, reversing cognitive deficits in animal models of Alzheimer’s disease.

Product Info

Cas No.

153559-49-0

Purity

≥98%

Formula

C24H28O2

Formula Wt.

348.48

Chemical Name

4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid

IUPAC Name

4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid

Synonym

Targretin, Targretyn, LGD-1069

Solubility

Practically insoluble in water. Soluble in DMSO (≥60 mg/ml).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B1992 MSDS PDF

Info Sheet

B1992 Info Sheet PDF

References

McFarland K, Spalding TA, Hubbard D, et al. Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson's Disease. ACS Chem Neurosci. 2013 Oct 11. [Epub ahead of print]. PMID: 24117438.

Schadt CR. Topical and oral bexarotene. Dermatol Ther. 2013 Sep;26(5):400-3. PMID: 24099070.

Aicardi G. New Hope from an Old Drug: Fighting Alzheimer's Disease with the Cancer Drug Bexarotene (Targretin)? Rejuvenation Res. 2013 Sep 19. [Epub ahead of print]. PMID: 24047423.

Quéreux G, Saint-Jean M, Peuvrel L, et al. Bexarotene in cutaneous T-cell lymphoma: third retrospective study of long-term cohort and review of the literature. Expert Opin Pharmacother. 2013 Sep;14(13):1711-21. 10. PMID: 23837676.

Mukherjee R, Strasser J, Jow L, et al. RXR agonists activate PPARalpha-inducible genes, lower triglycerides, and raise HDL levels in vivo. Arterioscler Thromb Vasc Biol. 1998 Feb;18(2):272-6. PMID: 9484993.

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