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S-Acetyl-L-glutathione

Product ID A1016
Cas No. 3054-47-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $64.50 In stock
5 g $193.10 In stock
25 g $572.50 In stock
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Description

S-acetyl-L-glutathione is a glutathione derivative that can increase intracellular glutathione similar to a prodrug. It can be used to replenish the depletion of reduced glutathione occurring during HIV infection and to inhibit HIV replication. However, it was found to selectively induce apoptosis in human lymphoma cells, Daudi, Raji and Jurkat cells, by depleting the intracellular glutathione level rather than increase it.

Product Info

Cas No.

3054-47-5

Purity

≥98%

Formula

C12H19N3O7S

Formula Wt.

349.36

Chemical Name

5-[[3-acetylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-amino-5-oxopentanoic acid

IUPAC Name

γ-Glutamyl-S-acetylcysteinylglycine

Synonym

L-glutathione, S-acetyl

Melting Point

199-204°C (dec.)

Solubility

Soluble in hot water. Practically insoluble in cold water.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A1016 MSDS PDF

Info Sheet

A1016 Info Sheet PDF

References

Fraternale A1, Paoletti MF, Casabianca A, et.al. Inhibition of murine AIDS by pro-glutathione (GSH) molecules. Antiviral Res. 2008 Feb;77(2):120-7. PMID: 18164447

Locigno R1, Pincemail J, Henno A, et.al. S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Int J Oncol. 2002 Jan;20(1):69-75. PMID: 11743644

Galzigna L1, Rizzoli V, Schiappelli P et.al. S-acetyl- and S-phenylacetyl-glutathione as glutathione precursors in rat plasma and tissue preparations. Enzyme Protein. 1994-1995;48(2):98-104. PMID: 7581748

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