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(S)-ar-Turmerone

Product ID T8269
Cas No. 532-65-0
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $114.80 In stock
5 mg $436.50 In stock
10 mg $765.60 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

Aromatic turmerone is a sesquiterpene found in Curcuma (turmeric). This compound exhibits anti-inflammatory, anticonvulsant, antifungal, anticancer, and anti-metastatic activities. Aromatic turmerone suppresses production of IL-2 and IFN-γ in T cells. In animal models of chemically-induced seizures, aromatic turmerone limits epileptic activity. Additionally, turmerone also inhibits growth of dermatophytes in various models. In breast cancer cells, this compound decreases phosphorylation of NF-κB, PI3K, and Akt and suppresses signaling of ERK1/2, inhibiting cellular migration and invasion. In other models, aromatic turmerone does not inhibit tumor growth but does suppress the development of lymphocytic leukemia in improving T and B lymphocyte proliferation. Like other compounds derived from turmeric, aromatic turmerone may indirectly inhibit EGFR.

Product Info

Cas No.

532-65-0

Purity

≥97%

Formula

C15H20O

Formula Wt.

216.32

IUPAC Name

(6S)-2-Methyl-6-(4-methylphenyl)-2-hepten-4-one

Solubility

Hexane, Petrol ether, Ethanol

Appearance

Yellowish oil

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T8269 MSDS PDF

Info Sheet

T8269 Info Sheet PDF

References

Oh S, Han AR, Park HR, et al. Suppression of Inflammatory cytokine production by ar-Turmerone isolated from Curcuma phaeocaulis. Chem Biodivers. 2014 Jul;11(7):1034-41. PMID: 25044589.

Orellana-Paucar AM, Afrikanova T, Thomas J, et al. Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy. PLoS One. 2013 Dec 13;8(12):e81634. PMID: 24349101.

Jankasem M, Wuthi-Udomlert M, Gritsanapan W. Antidermatophytic Properties of Ar-Turmerone, Turmeric Oil, and Curcuma longa Preparations. ISRN Dermatol. 2013 Aug 26;2013:250597. PMID: 24066236.

Sun M, Ma WN, Guo Y, et al. Simultaneous screening of four epidermal growth factor receptor antagonists from Curcuma longa via cell membrane chromatography online coupled with HPLC-MS. J Sep Sci. 2013 Jul;36(13):2096-103. PMID: 23640922.

Kim D, Suh Y, Lee H, et al. Immune activation and antitumor response of ar-turmerone on P388D1 lymphoblast cell implanted tumors. Int J Mol Med. 2013 Feb;31(2):386-92. PMID: 23229920.

Park SY, Kim YH, Kim Y, et al. Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells. J Cell Biochem. 2012 Dec;113(12):3653-62. PMID: 22740037.

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