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Cantharidin

Product ID C0255
Cas No. 56-25-7
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $88.00 In stock
100 mg $257.90 In stock
500 mg $940.60 In stock
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  • Description
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Description

Canthardin is a toxin secreted by many species of the blister beetle, Canarthis vesicatoria. Canthardin competitively inhibits serine/threonine phosphatases such as protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Canthardin exhibits anticancer and anti-resorptive activities. In cancer cells, canthardin upregulates expression of caspase 1 and the NGF receptor and downregulates expression of Bcl-2-like protein 10, Fas ligand, and TNF-α. In colorectal cancer cells, canthardin inhibits heat shock factor 1 and downstream HSP70- and BAG3-related signaling, inhibiting cell proliferation. Additionally, cantharidin displays pro-inflammatory activity in vivo, producing increases in MCP-1, IL-6, IL-1β, and myeloperoxidase. In vitro, this compound inhibits RANKL-induced expression of Fra-2 and cathepsin K and inhibits activation of ERK and MAPK signaling; these actions result in inhibition of differentiation and resorptive activity.

Product Info

Cas No.

56-25-7

Purity

≥98%

Formula

C10H12O4

Formula Wt.

196.20

Chemical Name

(1S,2R,6S,7R)-2,6-dimethyl-4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione

IUPAC Name

(1S,2R,6S,7R)-2,6-dimethyl-4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione

Synonym

Kantaridin

Melting Point

212°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C0255 MSDS PDF

Info Sheet

C0255 Info Sheet PDF

References

Chen X, Liu J, Zhang Y. Cantharidin impedes the activity of protein serine/threonine phosphatase in Plutella xylostella. Mol Biosyst. 2013 Nov 19. [Epub ahead of print]. PMID: 24253262.

Kadioglu O, Kermani NS, Kelter G, et al. Pharmacogenomics of Cantharidin in Tumor Cells. Biochem Pharmacol. 2013 Nov 11. pii: S0006-2952(13)00709-0. Epub ahead of print]. PMID: 24231507.

Kim JA, Kim Y, Kwon BM, et al. The natural compound cantharidin induces cancer cell death through inhibition of heat shock protein 70 (HSP70) and Bcl-2-associated athanogene domain 3 (BAG3) expression by blocking heat shock factor 1 (HSF1) binding to promoters. J Biol Chem. 2013 Oct 4;288(40):28713-26. PMID: 23983126.

Ivetic Tkalcevic V, Hrvacic B, Bosnar M, et al. Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories. Transl Res. 2012 Aug;160(2):137-45. PMID: 22677362.

Kim MH, Shim KS, Kim SH. Inhibitory effect of cantharidin on osteoclast differentiation and bone resorption. Arch Pharm Res. 2010 Mar;33(3):457-62. PMID: 20361312.

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