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Dapiprazole Hydrochloride

Dapiprazole Hydrochloride

Product ID D0262
Cas No. 72822-13-0
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $95.70 In stock
25 mg $214.00 In stock
100 mg $704.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Dapiprazole is an α1-adrenergic antagonist that displays preference for α1A and α1D receptors over α1B receptors. Dapiprazole is used as a miotic compound, evoking pupillary constriction and reversing mydriasis or dilation. Additionally, dapiprazole decreases mean intraocular pressure in patients with glaucoma. Dapiprazole also decreases pigment shedding and increases outflow facility and pigment clearance in patients with pigmentary glaucoma.

Product Info

Cas No.

72822-13-0

Purity

≥98%

Formula

C19H27N5 • HCl

Formula Wt.

361.91

Chemical Name

3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine;hydrochloride

IUPAC Name

3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2, 4]triazolo[4,3-a]pyridine;hydrochloride

Synonym

Rev-Eyes

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D0262 MSDS PDF

Info Sheet

D0262 Info Sheet PDF

References

Eltze M. Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D. J Pharm Pharmacol. 1997 Nov;49(11):1091-5. PMID: 9401944.

Hogan TS, McDaniel DD, Bartlett JD, et al. Dose-response study of dapiprazole HCl in the reversal of mydriasis induced by 2.5% phenylephrine. J Ocul Pharmacol Ther. 1997 Aug;13(4):297-302. PMID: 9261765.

Mastropasqua L, Carpineto P, Ciancaglini M, et al. The usefulness of dapiprazole, an alpha-adrenergic blocking agent, in pigmentary glaucoma. Ophthalmic Surg Lasers. 1996 Sep;27(9):806-9. PMID: 8878205.

Mastropasqua L, Carpineto P, Ciancaglini M, et al. Effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in pigmentary glaucoma. Ophthalmic Res. 1996;28(5):312-8. PMID: 8979280.

Nyman N, Reich L. The effect of dapiprazole on accommodative amplitude in eyes dilated with 0.5 percent tropicamide. J Am Optom Assoc. 1993 Sep;64(9):625-8. PMID: 7901257.

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