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Rufloxacin is a fluoroquinolone antibiotic that exhibits antibacterial activity against both gram negative and gram positive bacteria such as Escherichia and Helicobacter. Rufloxacin inhibits topoisomerase IV and DNA gyrase. Under UV exposure, rufloxacin induces type II guanine oxidation, increasing DNA base oxidation and displaying mutagenic/carcinogenic potential.
| Cas No. | 106017-08-7 |
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| Purity | ≥98% |
| Formula | C17H18FN3O3S • HCl |
| Formula Wt. | 399.87 |
| Chemical Name | 9-Fluro-2,3-dihydro-10-(4-methyl-1-piperazinyl)-7- oxo-7H-pyridol[1,2,3-de]-1,4-benzothiazine-6-carboxylic acid hydrochloride |
| IUPAC Name | 7-fluoro-6-(4-methylpiperazin-1-yl)-10-oxo-4-thia-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid;hydrochloride |
| Synonym | Qari, Monos, Tebraxin |
| Melting Point | 322-324°C |
| Appearance | Slightly yellow-green crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Gu LY, Lin WW, Lu H, et al. Quadruple therapy with medications containing either rufloxacin or furazolidone as a rescue regimen in the treatment of Helicobacter pylori-infected dyspepsia patients: a randomized pilot study. Helicobacter. 2011 Aug;16(4):284-8. PMID: 21762267.
Belvedere A, Boscá F, Catalfo A, et al. Type II guanine oxidation photoinduced by the antibacterial fluoroquinolone Rufloxacin in isolated DNA and in 2'-deoxyguanosine. Chem Res Toxicol. 2002 Sep;15(9):1142-9. PMID: 12230407.
Montanari MP, Prenna M, Mingoia M, et al. In vitro antibacterial activity of trovafloxacin and five other fluoroquinolones. Chemotherapy. 1998 Mar-Apr;44(2):85-93. PMID: 9551237.