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Berberine Chloride

Berberine Chloride

Product ID B1870
Cas No. 633-65-8
Purity ≥97%
Product Unit SizeCostQuantityStock
5 g $59.50 In stock
10 g $81.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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  • Custom Order

Description

Berberine is an isoquinoline alkaloid found in a variety of plants, including barberry, goldenseal, Oregon grape, California poppy, and the Amur cork tree. Berberine fluoresces under ultraviolet light and is often used to stain heparin in mast cells. Berberine displays many beneficial effects, including immunomodulatory, anticancer, anti-inflammatory, antiviral, lipid-lowering, and antidepressant activities. This compound is a competitive inhibitor of both acetylcholinesterase (AChE) and prolyl oligopeptidase, enzymes important in neuropsychiatric disorders such as Alzheimer’s Disease, depression, schizophrenia, and anxiety. In animal models of depression, berberine increases levels of 5-HT, DA, and NE and is also thought to act on σ receptors. Berberine suppresses hedgehog (Hh) signaling, likely through inhibition of the Smoothened (Smo) receptor.

Product Info

Cas No.

633-65-8

Purity

≥97%

Formula

C20H18NO4 • Cl

Formula Wt.

371.82

IUPAC Name

16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene;chloride

Melting Point

200°C

Solubility

Soluble in boiling water. Slightly soluble in cold water. Soluble in methanol >20 mg/mL. Soluble in ethanol >2 mg/mL. Soluble in DMSO 74 mg/mL. Slightly soluble in chloroform.

Appearance

Yellow crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B1870 MSDS PDF

Info Sheet

B1870 Info Sheet PDF

Brochures

Hedgehog Signaling Flyer

References

Wang J, Peng Y, Liu Y, et al. Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth. BMC Cancer. 2015 Aug 22;15:595.

Huang L, Shi A, He F, et al. Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors. Bioorg Med Chem. 2010 Feb;18(3):1244-51. PMID: 20056426.

Tarrago T, Kichik N, Seguí J, et al. The natural product berberine is a human prolyl oligopeptidase inhibitor. ChemMedChem. 2007 Mar;2(3):354-9. PMID: 17295371.

Kulkarni SK, Dhir A. Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytother Res. 2010 Mar;24(3):317-24. PMID: 19998323.

Kulkarni SK, Dhir A. On the mechanism of antidepressant-like action of berberine chloride. Eur J Pharmacol. 2008 Jul 28;589(1-3):163-72. PMID: 18585703.

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