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Tetrodotoxin Citrate

Product ID T1878
Cas No. 18660-81-6
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $354.30 In stock
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  • Product Info
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  • Description
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Description

Tetrodotoxin (TTX) is a neurotoxin used in research models that inhibits neuronal voltage-gated Na+ channels at site 1. TTX can be found in Tetraodontiformes fish such as the puffer fish and ocean sunfish; it exhibits neuromodulatory and analgesic activities. In subjects experiencing cancer pain, TTX decreases reported pain levels. This compound is primarily used to study neuronal transmission and analgesia.

Product Info

Cas No.

18660-81-6

Purity

≥99%

Formula

C11H17N3O8 • C6H8O7

Formula Wt.

511.39

Chemical Name

(1R,5R,6R,7S,9S,11R,13S)-3-Amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.17,11.01,6]tetradec-2-ene-5,9,12,13,14-pentol

IUPAC Name

(1R,5R,6R,7S,9S,11R,13S)-3-Amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.17,11.01,6]tetradec-2-ene-5,9,12,13,14-pentol

Synonym

TTX

Solubility

Soluble in water.

Appearance

White to off-white powder.

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T1878 MSDS PDF

Info Sheet

T1878 Info Sheet PDF

References

Matson DJ, Hamamoto DT, Bregman H, et al. Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain. PLoS One. 2015 Sep 17;10(9):e0138140. PMID: 26379236.

Eberhardt E, Havlicek S, Schmidt D, et al. Pattern of Functional TTX-Resistant Sodium Channels Reveals a Developmental Stage of Human iPSC- and ESC-Derived Nociceptors. Stem Cell Reports. 2015 Sep 8;5(3):305-13. PMID: 26321143.

Puilingi CG, Kudo Y, Cho Y, et al. Tetrodotoxin and Its Analogues in the Pufferfish Arothron hispidus and A. nigropunctatus from the Solomon Islands: A Comparison of Their Toxin Profiles with the Same Species from Okinawa, Japan. Toxins (Basel). 2015 Aug 26;7(9):3436-54. PMID: 26343722.

Hagen NA, Lapointe B, Ong-Lam M, et al. A multicentre open-label safety and efficacy study of tetrodotoxin for cancer pain. Curr Oncol. 2011 Jun;18(3):e109-16. PMID: 21655148.

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