• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Sanguinarine Chloride

Sanguinarine Chloride

Product ID S0254
Cas No. 5578-73-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $126.20 In stock
25 mg $449.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Sanguinarine is a benzophenanthridine alkaloid that exhibits a wide variety of beneficial properties, including anticancer, anti-inflammatory, and antibacterial activities. In breast cancer cells, sanguinarine increases levels of tissue inhibitor of metalloproteinase 1 and 2 (TIMP1 and TIMP2) and heme-oxygenase 1 (HO-1), decreases expression of matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), and COX-2, and inhibits the phosphorylation of Akt and ERK as well as the activation of NF-κB. Sanguinarine also inhibits VEGF release and increases levels of ROS, inducing apoptosis and inhibiting growth of mammary adenocarcinoma cells. In animal models of colitis, this compound decreases expression of IL-6, NF-κB, and TNF-α, resulting in decreases in weight loss, disease activity, and mortality. Sanguinarine increases oxidative stress and induces DNA damage in species of Microcystis, a cyanobacterium, inhibiting cell division. In species of Bacillus, this compound decreases bacterial membrane potential. Sanguinarine may also inhibit tubulin polymerization, allosterically activate AMPK, and inhibit amino acid carboxylase.

Product Info

Cas No.

5578-73-4

Purity

≥98%

Formula

C20H14ClNO4

Formula Wt.

367.78

Chemical Name

24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene;chloride

IUPAC Name

13-Methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium chloride

Synonym

Viadent

Solubility

Soluble in methanol, water (slightly), DMSO (10 mM), and ethanol (5 mM).

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S0254 MSDS PDF

Info Sheet

S0254 Info Sheet PDF

References

Park SY, Jin ML, Kim YH, et al. Sanguinarine inhibits invasiveness and the MMP 9 and COX 2 expression in TPA-induced breast cancer cells by inducing HO-1 expression. Oncol Rep. 2014 Jan;31(1):497-504. PMID: 24220687.

Shao J, Liu D, Gong D, et al. Inhibitory effects of sanguinarine against the cyanobacterium Microcystis aeruginosa NIES-843 and possible mechanisms of action. Aquat Toxicol. 2013 Oct 15;142-143:257-63. PMID: 24060579.

Dong XZ, Zhang M, Wang K, et al. Sanguinarine inhibits vascular endothelial growth factor release by generation of reactive oxygen species in MCF-7 human mammary adenocarcinoma cells. Biomed Res Int. 2013;2013:517698. PMID: 23762849.

Niu X, Fan T, Li W, et al. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):256-65. PMID: 23352506.

Foss MH, Eun YJ, Grove CI, et al. Inhibitors of bacterial tubulin target bacterial membranes in vivo. Medchemcomm. 2013 Jan 1;4(1):112-119. PMID: 23539337.

Choi J, He N, Sung MK, et al. Sanguinarine is an allosteric activator of AMP-activated protein kinase. Biochem Biophys Res Commun. 2011 Sep 23;413(2):259-63. PMID: 21884681.

Drsata J, Ulrichová J, Walterová D. Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase. J Enzyme Inhib. 1996;10(4):231-237. PMID: 8872743.

Wolff J, Knipling L. Antimicrotubule properties of benzophenanthridine alkaloids. Biochemistry. 1993 Dec 7;32(48):13334-9. PMID: 7902132.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E0001

    E64

    Cysteine protease inhibitor.

    ≥99%
  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%
  • O1179

    n-Octyl-4-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥98%
  • C9879

    Cytochalasin B

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • C1644

    Celecoxib

    NSAID; COX-2 inhibitor.

    ≥99%
  • D1643

    Delta Sleep Inducing Peptide

    Peptide; GABA potentiator, NMDA negative allost...

    ≥95%
  • V3455

    Vinpocetine

    Targets nuclear factor kappa B activation.

    ≥98%
  • C1649

    β-Cembrenediol

    Diterpene found in Anisomeles.

    ≥99%
  • Z5744

    Zoledronic Acid Hydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • C5655

    α-Conotoxin GI

    Peptide toxin found in Conus snails; nAChR inhi...

    ≥95%
  • A7618

    Atenolol

    β1-adrenergic antagonist.

    ≥98%
  • P3269

    Piroxicam

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • N0161

    β-Naphthoflavone

    AhR agonist.

    ≥98%
  • L1682

    Levamisole Hydrochloride

    Imidazothiazole; alkaline phosphatase inhibitor...

    ≥98%
  • A761001

    AT-7519 free base

    ATP competitive CDK inhibitor.

    ≥98%
  • G3353

    Ginkgolic Acid (15:1)

    Found in Ginkgo; HIV protease and fatty acid sy...

    ≥98%
  • D3320

    Difenoconazole

    Triazole; 14-α demethylase inhibitor, potentia...

    ≥98%
  • N0061

    D-Naproxen

    NSAID; COX-1/2 inhibitor.

    ≥99%
  • L0248

    Laminin Peptide YIGSR

    Laminin-derived peptapeptide.

    ≥98%
  • H9861

    Hypericin

    Naphthodianthrone found in Hypericum; dopamine ...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only