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Ginkgolic Acid (15:1)

Ginkgolic Acid (15:1)

Product ID G3353
Cas No. 22910-60-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $359.70 In stock
5 mg $1,198.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
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  • Downloads
  • References
  • Description
  • Product Info
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Description

Ginkgolic acids are found in Ginkgo biloba and exhibit antiviral, antibiotic, and anticancer chemotherapeutic activities. In vitro, ginkgolic acids inhibit HIV protease and suppress HIV infection. Ginkgolic acids also exhibit antibacterial efficacy against both gram positive and gram negative bacteria, including Staphylococcus, Escherichia, and Bacillus. Ginkgolic acids also inhibit fatty acid synthase and exhibit cytotoxicity in breast cancer, lung cancer, and leukemia cells. Additionally, ginkgolic acids induce apoptosis in cancer cells through downregulation of Bcl-2 and upregulation of Bax. Ginkgolic acids may also be neurotoxic, as they increase activity of protein phosphatase 2C (PP2C) in neurons.

Product Info

Cas No.

22910-60-7

Purity

≥98%

Formula

C22H34O3

Formula Wt.

346.50

IUPAC Name

2-hydroxy-6-[(Z)-pentadec-8-enyl]benzoic acid

Synonym

Romanicardic acid, Anacardic acid 15:1, Ginkgolic Acid I

Melting Point

136-137°C

Solubility

Soluble in acetone.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G3353 MSDS PDF

Info Sheet

G3353 Info Sheet PDF

Brochures

Antivirals Booklet

References

Fu Y, Hong S, Li D, et al. Novel chemical synthesis of ginkgolic acid (13:0) and evaluation of its tyrosinase inhibitory activity. J Agric Food Chem. 2013 Jun 5;61(22):5347-52. PMID: 23701207.

Oh J, Hwang IH, Hong CE, et al. Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity. J Enzyme Inhib Med Chem. 2013 Jun;28(3):565-8. PMID: 22380770.

Lü JM, Yan S, Jamaluddin S, et al. Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Med Sci Monit. 2012 Aug;18(8):BR293-298. PMID: 22847190.

Zhou C, Li X, Du W, et al. Antitumor effects of ginkgolic acid in human cancer cell occur via cell cycle arrest and decrease the Bcl-2/Bax ratio to induce apoptosis. Chemotherapy. 2010;56(5):393-402. PMID: 20948210.

Yang X, Chen J, Qian Z, et al. Study on the antibacterial activity of ginkgolic acids. Zhong Yao Cai. 2002 Sep;25(9):651-3. PMID: 12451978.

Ahlemeyer B, Selke D, Schaper C, et al. Ginkgolic acids induce neuronal death and activate protein phosphatase type-2C. Eur J Pharmacol. 2001 Oct 26;430(1):1-7. PMID: 11698056.

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