LKT Labs

Biochemicals for Life Science Research

Actinomycin

Actinomycin

Product ID A0977
Cas No. 50-76-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $115.60 In stock
10 mg $207.90 In stock
Bulk Quote

Quicklinks

Description

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA, preventing chain elongation and inhibiting RNA polymerase and topoisomerase activity. In cellular and animal models of chronic lymphocytic leukemia (CLL), this compound downregulates expression of Bcl-2 and Mcl-1, induces apoptosis, inhibits cellular proliferation, and decreases tumor burden.

Product Info

Cas No.

50-76-0
Purity

≥98%
Formula

C62H86N12O16
Formula Wt.

1255.50
IUPAC Name

2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12, 15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11, 14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Synonym

Actinomycin D, Meractinomycin, Dactinomycin
Melting Point

245-255°C (dec.)
Solubility

Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50 mg/mL), methanol (10 mg/mL).
Appearance

Salmon Pink Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

A0977 MSDS PDF
Info Sheet

A0977 Info Sheet PDF

References

Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622.

Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596.

Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E7230

    Ethambutol Dihydrochloride

    Arabinosyl transferase inhibitor.

    ≥98%
  • C4657

    Clotrimazole

    Imidazole; 14-α demethylase, H+/K+ ATPase, Na+...

    ≥97%
  • T165133

    Tedizolid Phosphate

    Effective against gram-positive pathogens

    ≥98%
  • V9202

    VX-702

    p38 MAPK inhibitor.

    ≥98%
  • L1881

    Leuprolide Acetate

    GnRH analog; GnRH1 agonist.

    ≥95%
  • E5369

    Enrofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • P3576

    Pitavastatin Calcium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • F4883

    Flutriafol

    Triazole; demethylation inhibitor, NMDA agonist...

    ≥97%
  • C2900

    CH5424802

    ALK inhibitor.

    ≥99%
  • D3221

    Difluoromethylornithine Hydrochloride Monohydrate

    Ornithine decarboxylase inhibitor.

    ≥98%
  • A5135

    Aminophylline Dihydrate

    Xanthine derivative; adenosine antagonist, PDE ...

    ≥98%
  • D3351

    4-Dimethylaminopyridine

    Acyl transfer catalyst, involved in peptide syn...

    ≥98%
  • M1746

    Melphalan

    Nitrogen mustard, DNA alkylator.

    ≥95%
  • S6233

    Spiramycin Hexanedioate

    Macrolide; protein synthesis inhibitor.

    ≥90%
  • C0020

    Cafestol

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • I0417

    R-(−)-Iberin

    Sulforaphane homolog, ITC found in cruciferous ...

    ≥98%
  • D336486

    Dimethylamino Parthenolide

    Water-soluble parthenolide analog; NF-κB inhib...

    ≥98%
  • L5769

    Lorglumide Sodium

    CCK antagonist.

    ≥98%
  • R5700

    Ro 61-8048

    Kynurenine 3-hydroxylase inhibitor.

    ≥99%
  • B3374

    Bisacodyl

    Diphenylmethane derivative, stimulates colonic ...

    ≥98%