Actinomycin

Product ID A0977

Cas No. 50-76-0

Purity ≥98%

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Product Info
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Description
Product Info
Shipping and Storage
Downloads
References
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Description

Actinomycin D is a polypeptide antibiotic produced from Streptomyces; it exhibits anticancer chemotherapeutic activity but does not display antibacterial benefit. Actinomycin D is clinically used to treat various cancers and is one component of the VAC chemotherapy regimen. Actinomycin D binds DNA, preventing chain elongation and inhibiting RNA polymerase and topoisomerase activity. In cellular and animal models of chronic lymphocytic leukemia (CLL), this compound downregulates expression of Bcl-2 and Mcl-1, induces apoptosis, inhibits cellular proliferation, and decreases tumor burden.

Product Info

Cas No.	50-76-0
Purity	≥98%
Formula	C₆₂H₈₆N₁₂O₁₆
Formula Wt.	1255.50
IUPAC Name	2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12, 15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11, 14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
Synonym	Actinomycin D, Meractinomycin, Dactinomycin
Melting Point	245-255°C (dec.)
Solubility	Soluble in ethanol, propylene glycol, water + glycol mixture. Soluble in DMSO (50 mg/mL), methanol (10 mg/mL).
Appearance	Salmon Pink Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	A0977 MSDS PDF
Info Sheet	A0977 Info Sheet PDF

References

Merkel O, Wacht N, Sifft E, et al. Actinomycin D induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia. Leukemia. 2012 Dec;26(12):2508-16. PMID: 22743622.

Koba M, Konopa J. Actinomycin D and its mechanisms of action. Postepy Hig Med Dosw (Online). 2005;59:290-8. PMID: 15995596.

Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31. PMID: 2410919.