LKT Labs

Biochemicals for Life Science Research

Urocortin, human

Product ID U6854
Cas No. 171543-83-2
Purity ≥98%
Product Unit SizeCostQuantityStock
0.5 mg $370.90 In stock
1 mg $630.30 Please Inquire
2.5 mg $1,112.60 Please Inquire
Bulk Quote

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Description

Urocortin is an endogenous peptide ligand and member of the corticotropin-releasing factor (CRF) family; it binds and activates CRF type 1 and 2 receptors. Urocortin modulates stress responses and exhibits anorexigenic, anxiogenic, and positive inotropic effects across a wide variety of in vivo models. Urocortin is primarily expressed in the heart. Urocortin exerts many effects on signaling of the hypothalamic-pituitary-adrenal (HPA) axis, including increasing corticosterone and adrenocorticotropic hormone (corticotropin) levels.

Product Info

Cas No.

171543-83-2
Purity

≥98%
Formula

C204H337N63O64
Formula Wt.

4696.3
Solubility

Soluble in water (1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

U6854 MSDS PDF
Info Sheet

U6854 Info Sheet PDF

References

Bagosi Z, Csabafi K, Palotai M, et al. The effect of urocortin I on the hypothalamic ACTH secretagogues and its impact on the hypothalamic-pituitary-adrenal axis. Neuropeptides. 2013 Nov 21. pii: S0143-4179(13)00100-5. PMID: 24331779.

Dono LM, Currie PJ. The cannabinoid receptor CB1 inverse agonist AM251 potentiates the anxiogenic activity of urocortin I in the basolateral amygdala. Neuropharmacology. 2012 Jan;62(1):192-9. PMID: 21736884.

Currie PJ, Coiro CD, Duenas R, et al. Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization. Brain Res. 2011 Apr 18;1385:127-34. PMID: 21303672.

Takahashi K, Totsune K, Murakami O, et al. Urocortins as cardiovascular peptides. Peptides. 2004 Oct;25(10):1723-31. PMID: 15476939.

Suda T, Kageyama K, Sakihara S, et al. Physiological roles of urocortins, human homologues of fish urotensin I, and their receptors. Peptides. 2004 Oct;25(10):1689-701. PMID: 15476936.

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