• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Mechlorethamine Hydrochloride

Mechlorethamine Hydrochloride

Product ID C2942
Cas No. 55-86-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $50.50 In stock
1 g $90.50 In stock
5 g $169.60 In stock
10 g $300.00 In stock
25 g $522.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mechlorethamine is a nitrogen mustard DNA alkylator that binds and alkylates the N7 nitrogen on guanine and adenine bases in DNA. Mechlorethamine was initially developed as a blistering agent for use in chemical warfare but has since exhibited anticancer chemotherapeutic benefit. In vitro and in vivo, mechlorethamine forms a reactive aziridinium ion intermediate; it also can induce 5’-GNC-3’ DNA crosslinks. Additionally, this compound exhibits pro-oxidative activity, increasing levels of ROS and RNS in the treatment of B-cell chronic lymphocytic leukemia (CLL), inducing oxidative stress and apoptosis.

Product Info

Cas No.

55-86-7

Purity

≥98%

Formula

C5H11Cl2N • HCl

Formula Wt.

192.51

Chemical Name

2-Chloro-N-(2-chloroethyl)-N-methylethanamine, N-Methylbis(2-chloroethyl)amine hydrochloride

IUPAC Name

2-chloro-N-(2-chloroethyl)-N-methylethanamine;hydrochloride

Synonym

Nitrogen mustard, Bis(2-Chloroethyl)methylamine

Melting Point

108-111°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C2942 MSDS PDF

Info Sheet

C2942 Info Sheet PDF

References

Polavarapu A, Stillabower JA, Stubblefield SG, et al. The mechanism of guanine alkylation by nitrogen mustards: a computational study. J Org Chem. 2012 Jul 20;77(14):5914-21. PMID: 22681226.

Wang F, Li F, Ganguly M, et al. A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards. Biochemistry. 2008 Jul 8;47(27):7147-57. PMID: 18549246.

Crater J, Kannan S. Molecular mechanism of nitrogen mustard induced leukocyte(s) chemotaxis. Med Hypotheses. 2007;68(2):318-9. PMID: 16997491.

Eder JP Jr, Chan VT, Ng SW, et al. DNA topoisomerase II alpha expression is associated with alkylating agent resistance. Cancer Res. 1995 Dec 15;55(24):6109-16. PMID: 8521401.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • Y4802

    YM-201636

    PIKfyve inhibitor.

    ≥98%
  • C167200

    Cefazolin

    Cephalosporin analogue

    ≥98%
  • R1724

    Regadenoson

    Adenosine A2A agonist.

    ≥99%
  • C2950

    Chloroquine Diphosphate

    Aminoquinoline, binds heme, causes cell lysis.<...

    ≥98%
  • G571344

    (±)-Goitrin

    Reduces production of thyroid hormones

    ≥98%
  • V5870

    Vortioxetine

    5-HT1A agonist, 5-HT1B partial agonist, 5-HT3A/...

    ≥99%
  • G4782

    Glucoraphenin Potassium

    Glucosinolate found in cruciferous vegetables.<...

    ≥98%
  • G6803

    Granuliberin R

    Antimicrobial peptide found in amphibians.

    ≥95%
  • E7758

    Etomidate

    GABA-A agonist.

    ≥99%
  • D3232

    3,3′-Diindolylmethane

    Indole found in cruciferous vegetables; AhR ago...

    ≥98%
  • M3584

    Mivacurium

    Non-depolarizing NMJ blocker; nAChR antagonist....

    ≥98%
  • F1652

    Fenbufen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • A7309

    Ascorbyl Palmitate

    Fat-soluble vitamin C derivative.

    ≥95%
  • A454470

    L-Allylglycine

    Inhibitor of glutamic acid decarboxylase (GAD)....

    ≥98%
  • G0175

    Gastric Inhibitory Peptide, human

    Endogenous peptide hormone, somatostatin analog...

    ≥95%
  • H1672

    Hesperetin

    Flavanone found in species of Citrus; L-type Ca...

    ≥97%
  • N7209

    NSC-207895

    Benzofuroxan derivative; MDMX inhibitor.

    ≥98%
  • N5769

    Norfloxacin Nicotinate

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • S6000

    Sparfloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C084099

    CCCP

    Efflux pump inhibitor

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only