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Quinacrine Dihydrochloride Dihydrate

Product ID Q8133
Cas No. 6151-30-0
Purity ≥97%
Product Unit SizeCostQuantityStock
1 g $41.00 In stock
5 g $81.90 In stock
10 g $145.60 In stock
25 g $305.70 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Quinacrine exhibits anti-parasitic, anti-protozoan, anticancer, and anti-inflammatory activities. Quinacrine alters cell membrane permeability and is clinically used to treat infections of Giardia. In colon cancer cells, quinacrine induces apoptosis, activates p53 and p21, and inhibits topoisomerase. In other cellular models, quinacrine decreases TNF-α, IL-1β, and CCL21 production, suppresses migration of dendritic cells, and inhibits activation of CD8+ T cells.

Product Info

Cas No.

6151-30-0

Purity

≥97%

Formula

C23H30ClN3O • 2HCl • 2H2O

Formula Wt.

508.92

Chemical Name

N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,-4-pentanediamine dihydrochloride dihydrate

IUPAC Name

4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1, 4-diamine;dihydrate;dihydrochloride

Synonym

Atebrine hydrochloride, RP-866, SN-390, Mepacrine

Melting Point

248-250°C(dec)

Solubility

Soluble in hot water. Slightly soluble in ethanol, methanol or water. Insoluble in ether, benzene or acetone.

Appearance

Bright yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

Q8133 MSDS PDF

Info Sheet

Q8133 Info Sheet PDF

References

Mohapatra P, Preet R, Das D, et al. Quinacrine-mediated autophagy and apoptosis in colon cancer cells is through a p53- and p21-dependent mechanism. Oncol Res. 2012;20(2-3):81-91. PMID: 23193914.

Gorbachev AV, Gasparian AV, Gurova KV, et al. Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation. Eur J Immunol. 2007 Aug;37(8):2257-67. PMID: 17634953.

Fasanmade AA, Owuor ED, Ee RP, et al. Quinacrine induces cytochrome c-dependent apoptotic signaling in human cervical carcinoma cells. Arch Pharm Res. 2001 Apr;24(2):126-35. PMID: 11339632.

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