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Clofazimine is an antimyobacterial agent used to treat leprosy. It acts by binding to guanine in DNA, inhibiting bacterial proliferation. It also is used to treat drug-resistant tuberculosis, which is caused by a mycobacterium strain that is related to the strain that causes leprosy.
| Cas No. | 2030-63-9 |
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| Purity | ≥99% |
| Formula | C27H22Cl2N4 |
| Formula Wt. | 473.40 |
| Chemical Name | N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine |
| IUPAC Name | N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine |
| Synonym | Lamprene, Lampren, Chlofazimine,Clofazimina, Clofaziminum |
| Solubility | Insoluble in water. Solubility in DMSO, 5 mg/mL with gentle warming. |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Cholo M., Mothiba M., et al. Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline. J Antimicrob Chemother. 72(2):338-53 (2017). PMID: 27798208.
Mirnejad R., Asadi A., et al. Clofazimine: A useful antibiotic for drug-resistant tuberculosis. 105:1353-59 (2018). PMID: 30021373.