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Oligomycin

Product ID O4533
Cas No. 1404-19-9
Purity ≥97%
Product Unit SizeCostQuantityStock
1 mg $51.20 In stock
5 mg $132.80 In stock
10 mg $260.50 In stock
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  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

This product consists of a mixture of oligomycins A, B and C. Oligomycins are macrolide antibiotics that exhibit antibacterial activity. Oligomycins suppress oxidative phosphorylation in the mitochondria by inhibiting K+-activated current of the Na+/K+ ATPase. In vitro, oligomycins inhibit IFN-γ- and TNF-α-induced reductions in transepithelial resistance and paracellular permeability. Oligomycins also inhibit the increase in expression and phosphorylation of MLC, preventing intestinal epithelial barrier dysfunction induced by inflammatory cytokines.

Product Info

Cas No.

1404-19-9

Purity

≥97%

IUPAC Name

(5Z,7E,21E)-4-ethyl-11,12,15,19-tetrahydroxy-6'-(2-hydroxypropyl)-5',10, 12,14,16,18,20,26,29-nonamethylspiro[24, 28-dioxabicyclo[23.3.1]nonacosa-5,7,21-triene-27,2'-oxane]-13,17, 23-trione

Synonym

Oligomycin complex

Melting Point

84-100°C

Solubility

Soluble in ethanol, DMSO, acetone.

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

O4533 MSDS PDF

Info Sheet

O4533 Info Sheet PDF

References

Liu H, Wang P, Cao M, et al. Protective role of oligomycin against intestinal epithelial barrier dysfunction caused by IFN-γ and TNF-α. Cell Physiol Biochem. 2012;29(5-6):799-808. PMID: 22613980.

Ding Y, Hao J, Rakowski RF. Effects of oligomycin on transient currents carried by Na+ translocation of Bufo Na+/K(+)-ATPase expressed in Xenopus oocytes. J Membr Biol. 2011 Oct;243(1-3):35-46. PMID: 21877177.

Bittar EE. Effect of inhibitors and uncouplers on the Na pump of the Maia muscle fibre. J Physiol. 1966 Nov;187(1):81-103. PMID: 5972170.

CHAPPELL JB, CROFTS AR. THE EFFECT OF ATRACTYLATE AND OLIGOMYCIN ON THE BEHAVIOUR OF MITOCHONDRIA TOWARDS ADENINE NUCLEOTIDES. Biochem J. 1965 Jun;95:707-16. PMID: 14342506.

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