URB602 is a monoacylglycerol lipase (MAGL) inhibitor. By inhibiting MAGL, it increases the amount of 2-arachicodonyl glycerol, which is a natural substrate for the cannabinoid receptors. URB602 shows anti-inflammatory properties in mice models, as well as anti-nociceptive properties. It also demonstrates neuroprotective effects in 7-day old rat pups. Pretreatment with URB602 lessened the effect of hypoxia-ischemic brain damage in rat pup models.
| Cas No. | 565460-15-3 |
|---|---|
| Purity | ≥98% |
| Formula | C19H21NO2 |
| Formula Wt. | 295.38 |
| Chemical Name | [1,1’-Biphenyl]-3-yl-carbamic acid cyclohexyl ester |
| IUPAC Name | cyclohexyl N-(3-phenylphenyl)carbamate |
| Solubility | DMSO (>10 mg/mL) |
| Appearance | White to off-white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Carloni S, Alonso-Alconada D, Girelli S et al. Pretreatment with the monoacyglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. Pediatr Res. 2012 Oct;72(4):400-6 PMID: 22821058.
King AR, Duranti A, Totini A et al. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonylglycerol degradation in intact brain slices. Chem Biol. 2007 Dec;14(12):1357-65. PMID:18096504.
Comelli F, Giagnoni G, Bettoni I et al. The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation. Br J Pharmacol. 2007 Nov;152(5):787-94. PMID:17700715.
