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Ramoplanin

Product ID R0351
Cas No. 76168-82-6
Purity ≥90%
Product Unit SizeCostQuantityStock
25 mg $108.20 In stock
100 mg $244.70 In stock
250 mg $491.90 In stock
Bulk Quote

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  • Product Info
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  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Ramoplanin is a peptide antibiotic that displays antibacterial activity against aerobic and anaerobic gram positive bacteria such as Clostridium difficile. Ramoplanin inhibits bacterial growth by binding lipid II and preventing cell wall peptidoglycan formation.

Product Info

Cas No.

76168-82-6

Purity

≥90%

Formula

C119H154ClN21O40

Formula Wt.

2554.06

IUPAC Name

2-[[(2R)-2-[[(2S)-2-[[2-[[2-[[(2S, 3S)-2-[[2-[[(2R)-5-amino-2-[[(2S)-2-[[(2S,3S)-2-[[(2R)-2-[[(2R)-2-[[(2R, 3S)-2-[[(2R)-5-amino-2-[[(2R)-2-[[4-amino-2-[[(2S)-4-amino-2-[[(2Z, 4Z)-octa-2, 4-dienoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-2-(4- hydroxycyclohexyl)acetyl]amino]pentanoyl]amino]-3-hydroxybutanoyl]amino] -2-(4-hydroxycyclohexyl)acetyl]amino]-2-(4-hydroxycyclohexyl)acetyl] amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]pentanoyl]amino] -2-(4-hydroxycyclohexyl)acetyl]amino]-3-hydroxybutanoyl]amino]-2-(4- hydroxycyclohexyl)acetyl]amino]acetyl]amino]-4-methylpentanoyl]amino] propanoyl]amino]-2-(3-chloro-4-hydroxycyclohexyl)acetic acid

Synonym

Antibiotic A, Ramoplanin Mix (A2>A3>A1)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R0351 MSDS PDF

Info Sheet

R0351 Info Sheet PDF

References

Mathur H, O'Connor PM, Hill C, et al. Analysis of anti-Clostridium difficile activity of thuricin CD, vancomycin, metronidazole, ramoplanin, and actagardine, both singly and in paired combinations. Antimicrob Agents Chemother. 2013 Jun;57(6):2882-6. PMID: 23571539.

Fulco P, Wenzel RP. Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. Expert Rev Anti Infect Ther. 2006 Dec;4(6):939-45. PMID: 17181409.

Farver DK, Hedge DD, Lee SC. Ramoplanin: a lipoglycodepsipeptide antibiotic. Ann Pharmacother. 2005 May;39(5):863-8. PMID: 15784805.

Hu Y, Helm JS, Chen L, et al. Ramoplanin inhibits bacterial transglycosylases by binding as a dimer to lipid II. J Am Chem Soc. 2003 Jul 23;125(29):8736-7. PMID: 12862463.

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