• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PF-03758309 Dihydrochloride

PF-03758309 Dihydrochloride

Product ID P2000
Cas No. 1279034-84-2
Purity ≥99%, ≥99%ee
Product Unit SizeCostQuantityStock
1 mg $105.30 In stock
5 mg $180.30 In stock
25 mg $480.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PF-03758309 is an ATP-competitive inhibitor of p21-activated kinase 4 (PAK4), a kinase typically upregulated in many cancers. This compound exhibits anticancer chemotherapeutic and anti-metastatic activities. Inhibition of PAK4 inhibits cell motility, proliferation, and survival in cellular models of cancer and suppresses tumor growth in animal models of cancer. PF-03758309 also inhibits fusion and migration of preosteoclasts, osteoclast differentiation, and podosome formation in cellular models of osteoclast-related disorders.

Product Info

Cas No.

1279034-84-2

Purity

≥99%, ≥99%ee

Formula

C25H30N8OS • 2HCl

Formula Wt.

563.55

IUPAC Name

N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide;hydrochloride

Synonym

PF-3758309 .2HCl

Solubility

Soluble in DMSO, water and alcohols.

Appearance

Off white to pale yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2000 MSDS PDF

Info Sheet

P2000 Info Sheet PDF

References

Choi SW, Yeon JT, Ryu BJ, et al. Repositioning Potential of PAK4 to Osteoclastic Bone Resorption. J Bone Miner Res. 2015 Jan 31. [Epub ahead of print]. PMID: 25640698.

Ryu BJ, Lee H, Kim SH, et al. PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings Mol Cell Biochem. 2014 Apr;389(1-2):69-77. PMID: 24366569.

Murray BW, Guo C, Piraino J, et al. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. PMID: 20439741.

www.clinicaltrials.gov/show/NCT00932126

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • U6873

    Ursodeoxycholic Acid

    Endogenous secondary bile acid.

    ≥98%
  • K0031

    Kahweol Acetate

    Diterpene found in coffee beans.

    ≥98%
  • T2834

    Thiolutin

    Dithiolopyrrolone; RNA polymerase inhibitor.

    ≥98%
  • A7577

    Astilbin

    Flavonoid found in various plant sources.

    ≥99%
  • P1969

    Perifosine

    Alkylphospholipid analog; Akt inhibitor.

    ≥98%
  • V5254

    Vincristine Sulfate

    Vinca alkaloid found in Catharanthus; microtubu...

    ≥98%
  • O7218

    Oseltamivir Phosphate

    Viral neuraminidase inhibitor, potential MAO-A ...

    ≥98%
  • D1774

    Desloratadine

    Loratadine metabolite; FIASMA, histamine H1 ant...

    ≥97%
  • D324090

    Diclofenac Impurity C

    Impurity of diclofenac

    ≥98%
  • V014457

    Valnemulin Hydrochloride

    Pleuromutilin

    ≥98%
  • C0245

    Calcitonin Gene Related Peptide, rat

    Endogenous calcitonin-family peptide, involved ...

    ≥95%
  • N3322

    Niflumic Acid

    NSAID; NMDA inverse agonist, T-type Ca2+ and Cl...

    ≥98%
  • N344786

    N-Nitroso Valsartan Methyl Ester

    Valsartan impurity

  • O7332

    OSI-027

    mTOR inhibitor.

    ≥99%
  • A2500

    AG-1478

    EGFR inhibitor.

    ≥98%
  • O4549

    Olmesartan Medoxomil

    AT1 inhibitor.

    ≥98%
  • L283720

    Losartan Carboxylic acid

    Active metabolite of losartan

    ≥ 99%
  • A0816

    Acemetacin

    Glycolic acid ester prodrug of indomethacin, NS...

    ≥98%
  • A5284

    [Val5]-Angiotensin II, human

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • M5756

    Montelukast Sodium

    CysLT1 antagonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only