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Phenyl Isothiocyanate

Product ID P2513
Cas No. 103-72-0
Purity ≥98%
Product Unit SizeCostQuantityStock
50 g $61.30 In stock
100 g $91.60 Please Inquire
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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
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  • Custom Order

Description

Phenyl isothiocyanate (ITC) exhibits antibiotic, anti-angiogenic, anti-inflammatory, antioxidative, anticancer chemotherapeutic, and chemopreventive activities. Phenyl isothiocyanate displays antibacterial efficacy against Escherichia and Staphylococcus, altering membrane function and inducing cell death. In other cellular models, this compound downregulates expression of VEGF and inflammatory cytokines and increases expression of IL-2 and TIMP. Additionally, phenyl isothiocyanate decreases PMA-induced superoxide anion levels, inhibits lipid peroxidation, scavenges hydroxyl radicals, and decreases formation and number of solid tumors in animal models. Like other ITCs, this compound also acts as a phase II enzyme inducer.

Product Info

Cas No.

103-72-0

Purity

≥98%

Formula

C7H5NS

Formula Wt.

135.19

Chemical Name

Isothiocyanato benzene

IUPAC Name

isothiocyanatobenzene

Synonym

PITC, Isothiocyanatobenzene, Phenyl mustard oil, Thiocarbanil

Melting Point

-21°C

Solubility

Insoluble in water. Soluble in alcohol, ether.

Appearance

green liquid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2513 MSDS PDF

Info Sheet

P2513 Info Sheet PDF

References

Abreu AC, Borges A, Simões LC, et al. Antibacterial activity of phenyl isothiocyanate on Escherichia coli and Staphylococcus aureus. Med Chem. 2013 Aug;9(5):756-61. PMID: 22974327.

Thejass P, Kuttan G. Inhibition of endothelial cell differentiation and proinflammatory cytokine production during angiogenesis by allyl isothiocyanate and phenyl isothiocyanate. Integr Cancer Ther. 2007 Dec;6(4):389-99. PMID: 18048887.

Manesh C, Kuttan G. Anti-tumour and anti-oxidant activity of naturally occurring isothiocyanates. J Exp Clin Cancer Res. 2003 Jun;22(2):193-9. PMID: 12866569.

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