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Veliparib

Veliparib

Product ID V1745
Cas No. 912444-00-9
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $75.10 In stock
5 mg $120.20 In stock
25 mg $368.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Veliparib is an oral poly(ADP-ribose) polymerase (PARP) inhibitor that shows anticancer chemotherapeutic and anti-inflammatory activities. Veliparib crosses the blood-brain barrier with a 3:1 plasma:brain drug ratio. Inhibition of PARP by veliparib prevents excessive inflammation in animal models of cystic fibrosis and inhibits repair of DNA damage caused by chemotherapy or radiation in a variety of cancer models.

Product Info

Cas No.

912444-00-9

Purity

≥99%

Formula

C13H16N4O

Formula Wt.

244.29

Chemical Name

2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide

IUPAC Name

2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide

Synonym

ABT-888

Solubility

DMSO (>15 mg/mL, or >50mM).

Appearance

off-white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V1745 MSDS PDF

Info Sheet

V1745 Info Sheet PDF

Brochures

PARP Inhibitors Flyer

References

Owonikoko TK, Zhang G, Deng X et al. Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer. Cancer Med. 2014 Dec;3(6):1579-94. PMID: 25124282.

Barazzuol L, Jena R, Burnet NG, et al. Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma. Radiat Oncol. 2013 Mar 19;8:65. PMID: 23510353.

Ta LE, Schmelzer JD, Bieber AJ, et al. A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy. PLoS One. 2013;8(1):e54161. PMID: 23326593.

Anjos SM, Robert R, Waller D, et al. Decreasing Poly(ADP-Ribose) Polymerase Activity Restores ΔF508 CFTR Trafficking. Front Pharmacol. 2012;3:165. PMID: 22988441.

Custom Order

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