Betamethasone Valerate

Name: Betamethasone Valerate
SKU: B1879
Availability: InStock

Product ID B1879

Cas No. 2152-44-5

Purity ≥98%

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Product Info
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References

Description

Betamethasone valerate (BMV) is a synthetic glucocorticoid that is commonly used to treat psoriasis and dermatitis. BMV exhibits immunomodulatory, anti-inflammatory, and vasoconstrictive activity in vitro and in vivo. Across animal models of varying ages, BMV impairs maturation and viability of Langerhans and epidermal cells. BMV also decreases endogenous phospholipase activity and inhibits vasodilatory responses in skin; this partial vasoconstriction decreases blood flow, often resulting in a decrease in local TGF-β1 levels.

Product Info

Cas No.	2152-44-5
Purity	≥98%
Formula	C₂₇H₃₇FO₆
Formula Wt.	476.58
IUPAC Name	[(8S,9R,10S,11S,13S,14S,16S, 17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13, 16-trimethyl-3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate
Melting Point	183.5°C
Solubility	Insoluble in water. Ethanol (62 mg/mL). Soluble in acetone, DMSO.
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	B1879 MSDS PDF
Info Sheet	B1879 Info Sheet PDF

References

Naldi L, Yawalkar N, Kaszuba A, et al. Efficacy and safety of the Betamethasone valerate 0.1% plaster in mild-to-moderate chronic plaque psoriasis: a randomized, parallel-group, active-controlled, phase III study. Am J Clin Dermatol. 2011 Jun 1;12(3):191-201. PMID: 21284407.

Meindl S, Vaculik C, Meingassner JG, et al. Differential effects of corticosteroids and pimecrolimus on the developing skin immune system in humans and mice. J Invest Dermatol. 2009 Sep;129(9):2184-92. PMID: 19295616.

Leivo T, Arjomaa P, Oivula J, et al. Differential modulation of transforming growth factor-beta by betamethasone-17- valerate and isotretinoin: corticosteroid decreases and isotretinoin increases the level of transforming growth factor-beta in suction blister fluid. Skin Pharmacol Appl Skin Physiol. 2000 May-Aug;13(3-4):150-6. PMID: 10859533.

Marks R, Sawyer M. Glucocorticoid-induced vasoconstriction in human skin. An inhibitory role on phospholipase A2 activity. Arch Dermatol. 1986 Aug;122(8):881-3. PMID: 2874773.