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ADX-47273

Product ID A1592
Cas No. 851881-60-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $88.60 In stock
5 mg $307.90 In stock
25 mg $1,096.40 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

ADX 47273 is a positive allosteric modulator of metabotropic glutamate receptor mGluR5 that displays antipsychotic, neuromodulatory, and cognition enhancing activities. In vivo, ADX 47273 increases waking and decreases deep sleep behaviors; it also increases late phase long-term potentiation (LTP) and enhances adaptive learning. In other animal models, ADX 47273 decreases amphetamine- and phencyclidine-induced hyperlocomotion and accumbal dopamine levels.

Product Info

Cas No.

851881-60-2

Purity

≥98%

Formula

C20H17F2N3O2

Formula Wt.

369.36

Chemical Name

Piperidine, 1-(4-fluorobenzoyl)-3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-, (3S)-

IUPAC Name

(4-fluorophenyl)-[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methanone

Synonym

ADX 47273; ADX47273; UNII-4C4P7L0W63; CHEMBL381055; J-502326

Solubility

DMSO 74 mg/mL Ethanol 30 mg/mL Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A1592 MSDS PDF

Info Sheet

A1592 Info Sheet PDF

References

Ahnaou A, Langlois X, Steckler T, et al. Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats. Psychopharmacology (Berl). 2015 Mar;232(6):1107-22. PMID: 25323624.

Xu J, Zhu Y, Kraniotis S, et al. Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning. Learn Mem. 2013 Jul 18;20(8):438-45. PMID: 23869026.

Kroker KS, Rast G, Rosenbrock H. Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP. Neuropharmacology. 2011 Sep;61(4):707-14. PMID: 21640734.

Schlumberger C, Pietraszek M, Gravius A, et al. Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity. Eur J Pharmacol. 2009 Nov 25;623(1-3):73-83. PMID: 19765575.

Liu F, Grauer S, Kelley C, et al. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008 Dec;327(3):827-39. PMID: 18753411.

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