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Niflumic acid is a fenamate non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and antipyretic activities. Niflumic acid inhibits COX-2, Cl- channels, GABA-A receptors, and T-type Ca2+ channels; it also acts as an inverse agonist at NMDA receptors. In vitro, niflumic acid inhibits TNF-α- and IL-1β-induced activation of NF-κB and expression of iNOS and indirectly activates AMPK.
| Cas No. | 4394-00-7 |
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| Purity | ≥98% |
| Formula | C13H9F3N2O2 |
| Formula Wt. | 282.22 |
| Chemical Name | 2-[[3-Trifluoromethyl)phenyl]amino]-3-pyridine- carboxylic acid |
| IUPAC Name | 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylic acid |
| Synonym | Actol, Forenol, Nifluril |
| Melting Point | 204°C |
| Solubility | Soluble in DMSO, ethanol, methanol or acetonitrile. |
| Appearance | Yellowish Microcrystal Compacted |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Balderas E, Ateaga-Tlecuitl R, Rivera M, et al. Niflumic acid blocks native and recombinant T-type channels. J Cell Physiol. 2012 Jun;227(6):2542-55. PMID: 21898399.
Chi Y, Li K, Yan Q, et al. Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J Pharmacol Exp Ther. 2011 Oct;339(1):257-66. PMID: 21765041.
Sinkkonen ST, Mansikkamäki S, Möykkynen T, et al. Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. Mol Pharmacol. 2003 Sep;64(3):753-63. PMID: 12920213.
Lerma J, Martín del Río R. Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation. Mol Pharmacol. 1992 Feb;41(2):217-22. PMID: 1371581.