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BGB-283

Product ID B242042
Cas No. 1446090-79-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $80.40 In stock
5 mg $204.00 In stock
25 mg $475.90 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

BGB-283 is a dual RAF/EGFR inhibitor. It inhibits BRAF(V600E)-activated ERK phosphorylation and cell proliferation in vitro. This activity slows cell proliferation and tumor growth in BRAF(V600E) colorectal cancer cell lines, something that BRAF inhibitors vemurafenib and dabrafenib have been unable to achieve.

Product Info

Cas No.

1446090-79-4

Purity

≥98%

Formula

C25H17F3N4O3

Formula Wt.

478.43

IUPAC Name

5-({(1R,1aS,6bR)-1-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one

Synonym

BGB 283, BGB283, Beigene-283, Lifirafenib

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B242042 MSDS PDF

Info Sheet

B242042 Info Sheet PDF

References

Tang Z., Yuan X., et al. BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 14(10):2187-97 (2015). PMID:26208524.

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