• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Ciclopirox Olamine

Ciclopirox Olamine

Product ID C3208
Cas No. 41621-49-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $75.90 In stock
5 g $241.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ciclopirox is a hydroxypyridone compound that exhibits antifungal, anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. This compound acts as a metal ion chelator, preventing peroxide degradation. Ciclopirox modulates generation of ROS in a PKA/Ras1/Ras2-dependent manner, inducing DNA damage and cell death in Candida and Saccharomyces. Ciclopirox also inhibits mTOR, enhancing anticancer activity of other compounds. In breast cancer, colon adenocarcinoma, and rhabdomyosarcoma cells, this compound downregulates expression of cyclins A, B1, D1, and E, suppresses CDK2 and CDK4, and upregulates expression of p21, inducing G0/G1 phase cell cycle arrest and caspase-mediated apoptosis. In animal models, ciclopirox inhibits tumor growth of breast cancer xenografts. Additionally, ciclopirox inhibits expression of VEGFR3, preventing activation of ERK1/2 and tube formation in vitro.

Product Info

Cas No.

41621-49-2

Purity

≥98%

Formula

C12H17NO2 • C2H7NO

Formula Wt.

268.36

IUPAC Name

2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one

Melting Point

143°C

Solubility

DMSO (<1 mg/mL), Water (<1 mg/mL), Ethanol (100 mg/mL), Ethanol/Water 1:1 (50 mg/mL), Ethanol/Water 2:1 (300 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C3208 MSDS PDF

Info Sheet

C3208 Info Sheet PDF

References

Sen S, Hassane DC, Corbett C, et al. Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity. Exp Hematol. 2013 Sep;41(9):799-807.e4. PMID: 23660068.

Belenky P, Camacho D, Collins JJ. Fungicidal drugs induce a common oxidative-damage cellular death pathway. Cell Rep. 2013 Feb 21;3(2):350-8. PMID: 23416050.

Luo Y, Zhou H, Liu L, et al. The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway. Oncogene. 2011 May 5;30(18):2098-107. PMID: 21217783.

Subissi A, Monti D, Togni G, et al. Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent. Drugs. 2010 Nov 12;70(16):2133-52. PMID: 20964457.

Zhou H, Shen T, Luo Y, et al. The antitumor activity of the fungicide ciclopirox. Int J Cancer. 2010 Nov 15;127(10):2467-77. PMID: 20225320.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C8017

    Cuelure

    Hormonal attractant for male Bactrocera flies.<...

    ≥97%
  • M5610

    Moclobemide

    MAO-A inhibitor.

    ≥98%
  • A9435

    Axitinib

    VEGFR inhibitor.

    ≥98%
  • A724092

    Asciminib Hydrochloride

    Allosteric inhibitor

    ≥98%
  • G6368

    GPR

    Peptide, fibrinogen E analog found in Amaranthu...

    ≥95%
  • L0211

    Lactulose

    Synthetic non-digestible disaccharide.

    ≥99%
  • D3322

    Diflunisal

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • G3458

    Ginsenoside Rg1

    Triterpene saponin found in species of Panax.

    ≥98%
  • T7232

    S-Trityl-L-cysteine

    Organosulfur found in garlic; kinesin Eg5 inhib...

    ≥98%
  • N859614

    NVP-LDE225

    Smo inhibitor.

    ≥98%
  • V3455

    Vinpocetine

    Targets nuclear factor kappa B activation.

    ≥98%
  • A1331

    Adipokinetic Hormone, locust

    Neuropeptide hormone found in insects, involved...

    ≥95%
  • C1635

    Ceftazidime Hydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥97%
  • T503720

    TMS

    Selective inhibitor of cytochrome P450 1B1 (CYP...

    ≥99%
  • A0778

    ABT-737

    BH3 mimetic; Bcl-2, Bxl-xl, Bcl-w inhibitor.

    ≥98%
  • L5767

    Loratadine

    Histamine H1 antagonist, FIASMA.

    ≥98%
  • B564086

    Boceprevir

    Inhibits HCV replication

    ≥98%
  • N1744

    Nelarabine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • P4560

    Proteolipid Protein (139-151)

    Immunodominant peptide fragment of PLP, used to...

    ≥95%
  • C002045

    Oxazolidine Cabazitaxel

    Synthesis impurity

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only