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NVP-LDE225

NVP-LDE225

Product ID N859614
Cas No. 956697-53-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $188.00 In stock
10 mg $300.40 In stock
25 mg $601.00 In stock
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  • Product Info
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  • Description
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Description

NVP-LDE225 is an inhibitor of Smo that prevents hedgehog (Hh) signaling; it exhibits anticancer chemotherapeutic and anti-metastatic activities. NVP-LDE225 is currently approved for the treatment of basal cell carcinoma but is also in clinical trials as a potential treatment for other cancers. In renal cell carcinoma cells, NVP-LDE225 inhibits cellular proliferation, migration, and invasion; in animal models, it increases survival rates and decreases tumor growth. NVP-LDE225 also inhibits cell viability in prostate cancer cells. In animal models of prostate cancer, this compound inhibits the epithelial-to-mesenchymal transition (EMT), induces apoptosis, decreases the expression of Bcl-2, Bcl-xl, XIAP, and survivin, and increases the expression of Bax and Bak; it also inhibits tumor growth. Smo antagonists such as NVP-LDE225 also cause alopecia, likely due to alteration in hair follicle embryology.

Product Info

Cas No.

956697-53-3

Purity

≥98%

Formula

C26H26F3N3O3

Formula Wt.

485.51

Chemical Name

N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide

IUPAC Name

N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide

Synonym

Erismodegib, Sonidegib, LDE225

Solubility

DMSO:97 mg/mL (199.79 mM) Ethanol:97 mg/mL warmed (199.79 mM) Water insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N859614 MSDS PDF

Info Sheet

N859614 Info Sheet PDF

References

Ferguson J, Hannam S, Toholka R, et al. Hair Loss and Hedgehog Inhibitors - A Class Effect? Br J Dermatol. 2014 Dec 18. [Epub ahead of print]. PMID: 25523648.

D'Amato C, Rosa R, Marciano R, et al. Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells. Br J Cancer. 2014 Sep 9;111(6):1168-79. PMID: 25093491.

Nanta R, Kumar D, Meeker D, et al. NVP-LDE-225 (Erismodegib) inhibits epithelial-mesenchymal transition and human prostate cancer stem cell growth in NOD/SCID IL2Rγ null mice by regulating Bmi-1 and microRNA-128. Oncogenesis. 2013 Apr 8;2:e42. PMID: 23567619.

Custom Order

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