Azaperone is a butyrophenone tranquilizer that exhibits sedative activity through the inhibition of α-adrenergic receptors. Azaperone also inhibits dopamine receptors and histamine receptors; it also may display antiemetic, antipsychotic, antihistaminergic, and anticholinergic activities.
| Cas No. | 1649-18-9 |
|---|---|
| Purity | ≥98% |
| Formula | C19H22FN3O |
| Formula Wt. | 327.40 |
| Chemical Name | 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1 -butanone |
| IUPAC Name | 1-(4-fluorophenyl)-4-(4-pyridin-2-ylpiperazin-1-yl)butan-1-one |
| Synonym | Stresnil, Suicalm |
| Melting Point | 73-75°C |
| Solubility | Soluble in chloroform and ethyl acetate. |
| Appearance | A White or Almost White Crystalline Powder |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Wolfe LL, Fisher MC, Davis TR, et al. Efficacy of a Low-Dosage Combination of Butorphanol, Azaperone, and Medetomidine (BAM) to Immobilize Rocky Mountain Elk. J Wildl Dis. 2014 Jul;50(3):676-80. PMID: 24807358.
McCormick AV, Wheeler JM, Guthrie CR, et al. Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biol Psychiatry. 2013 Mar 1;73(5):464-71. PMID: 23140663.
Mentaberre G, López-Olvera JR, Casas-Díaz E, et al. Use of haloperidol and azaperone for stress control in roe deer (Capreolus capreolus) captured by means of drive-nets. Res Vet Sci. 2010 Jun;88(3):531-5. PMID: 20006891.
Leysen JE, Gommeren W. The dissociation rate of unlabelled dopamine antagonists and agonists from the dopamine-D2 receptor, application of an original filter method. J Recept Res. 1984;4(7):817-45. PMID: 6527363.
